Product: TTC23 Antibody
Catalog: AF0706
Description: Rabbit polyclonal antibody to TTC23
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Dog
Mol.Wt.: 50kDa; 50kD(Calculated).
Uniprot: Q5W5X9
RRID: AB_2834283

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(91%), Bovine(91%), Horse(91%), Sheep(91%), Dog(90%)
Clonality:
Polyclonal
Specificity:
TTC23 Antibody detects endogenous levels of total TTC23.
RRID:
AB_2834283
Cite Format: Affinity Biosciences Cat# AF0706, RRID:AB_2834283.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Cervical cancer proto oncogene 8 protein; Cervical cancer proto-oncogene 8 protein; HCC 8; HCC-8; OTTHUMP00000190851; Protooncogene 8; Tetratricopeptide repeat domain 23; Tetratricopeptide repeat protein 23; TPR repeat protein 23; Ttc23; TTC23_HUMAN;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Description:
TTC23 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Sequence:
MQESQETHISNHLDEVVAAVSITHRKKFQNKLLQTALFQPPREKLHLCEEKAKSYSNSHEYKQAVHELVRCVALTRICYGDSHWKLAEAHVNLAQGYLQLKGLSLQAKQHAEKARQILANSIVPPYSENTDVFKFSIELFHTMGRALLSLQKFKEAAENLTKAERLSKELLQCGRIIKEEWIEIEARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQAHLIILSRSPSQVEAADSAHIVAHAAVASGRHEHHDVAEQYFQESMAHLKDSEGMGRTKFLSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKCLQIQTLLYGPQDKRTLATQQAMGMLSTAPKVASKPRQASKAKVAFCTSIPQDTLLGKARPGTTAD

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
91
Horse
91
Bovine
91
Sheep
91
Dog
90
Rabbit
73
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q5W5X9 As Substrate

Site PTM Type Enzyme
T161 Phosphorylation
S167 Phosphorylation
S415 Phosphorylation

Research Backgrounds

Function:

Participates positively in the ciliary Hedgehog (Hh) signaling.

Subcellular Location:

Cell projection>Cilium.
Note: Colocalizes with EVC and IQCE at the EvC zone of primary cilia.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Found Associated with the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC.

Restrictive clause

 

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