Product: TNFRSF17 Antibody
Catalog: DF10193
Description: Rabbit polyclonal antibody to TNFRSF17
Application: WB IF/ICC
Reactivity: Human, Rat
Prediction: Horse, Dog
Mol.Wt.: 20 kDa; 20kD(Calculated).
Uniprot: Q02223
RRID: AB_2840772

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Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Rat
Prediction:
Horse(92%), Dog(83%)
Clonality:
Polyclonal
Specificity:
TNFRSF17 Antibody detects endogenous levels of total TNFRSF17.
RRID:
AB_2840772
Cite Format: Affinity Biosciences Cat# DF10193, RRID:AB_2840772.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

B cell maturation antigen; B cell maturation factor; B cell maturation protein; B-cell maturation protein; BCM; BCMA; CD269; CD269 antigen; TNFRSF17; TNR17_HUMAN; Tumor necrosis factor receptor superfamily member 17;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q02223 TNR17_HUMAN:

Expressed in mature B-cells, but not in T-cells or monocytes.

Sequence:
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
92
Dog
83
Rabbit
75
Pig
64
Bovine
0
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q02223 As Substrate

Site PTM Type Enzyme
K86 Acetylation
K86 Ubiquitination
K106 Acetylation
K106 Ubiquitination
Y121 Phosphorylation
K133 Ubiquitination
K135 Ubiquitination
K137 Ubiquitination
K160 Ubiquitination
K166 Ubiquitination
S173 Phosphorylation
K179 Ubiquitination

Research Backgrounds

Function:

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Subcellular Location:

Cell membrane>Single-pass type III membrane protein. Endomembrane system>Single-pass type III membrane protein.
Note: Perinuclear Golgi-like structures.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in mature B-cells, but not in T-cells or monocytes.

Subunit Structure:

Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.

Research Fields

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Organismal Systems > Immune system > Intestinal immune network for IgA production.   (View pathway)

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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