SERPINA6 Antibody - #DF8283
Product: | SERPINA6 Antibody |
Catalog: | DF8283 |
Description: | Rabbit polyclonal antibody to SERPINA6 |
Application: | WB IF/ICC |
Reactivity: | Human |
Mol.Wt.: | 60 kDa; 45kD(Calculated). |
Uniprot: | P08185 |
RRID: | AB_2841570 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8283, RRID:AB_2841570.
Fold/Unfold
CBG; CBG_HUMAN; corticosteroid binding globulin; Corticosteroid-binding globulin; serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6; Serpin A6; serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6; Serpina6; Transcortin;
Immunogens
Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
- P08185 CBG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
PTMs - P08185 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
N31 | N-Glycosylation | Uniprot | |
S66 | Phosphorylation | Uniprot | |
S78 | Phosphorylation | Uniprot | |
N96 | N-Glycosylation | Uniprot | |
N330 | N-Glycosylation | Uniprot | |
N369 | N-Glycosylation | Uniprot |
Research Backgrounds
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.
Secreted.
Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids.
Belongs to the serpin family.
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