CD300A Antibody - #DF8434
| Product: | CD300A Antibody |
| Catalog: | DF8434 |
| Description: | Rabbit polyclonal antibody to CD300A |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Mol.Wt.: | 40~60 kDa; 33kD(Calculated). |
| Uniprot: | Q9UGN4 |
| RRID: | AB_2841680 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8434, RRID:AB_2841680.
Fold/Unfold
CD300 antigen-like family member A; CD300a; CD300a antigen; CD300a molecule; CLM-8; CLM8_HUMAN; CMRF 35 H9; CMRF-35-H9; CMRF35-H; CMRF35-H9; CMRF35-like molecule 8; CMRF35H; CMRF35H leukocyte immunoglobulin like receptor; CMRF35H9; IgSF12; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; IRC1; IRC1/IRC2; IRC2; IRp60; Leukocyte membrane antigen; Mast cell derived paired immunoglobulin like receptor 1; NK inhibitory receptor; Polymeric immunoglobulin receptor 4;
Immunogens
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
- Q9UGN4 CLM8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWLPWALLLLWVPGCFALSKCRTVAGPVGGSLSVQCPYEKEHRTLNKYWCRPPQIFLCDKIVETKGSAGKRNGRVSIRDSPANLSFTVTLENLTEEDAGTYWCGVDTPWLRDFHDPVVEVEVSVFPASTSMTPASITAAKTSTITTAFPPVSSTTLFAVGATHSASIQEETEEVVNSQLPLLLSLLALLLLLLVGASLLAWRMFQKWIKAGDHSELSQNPKQAATQSELHYANLELLMWPLQEKPAPPREVEVEYSTVASPREELHYASVVFDSNTNRIAAQRPREEEPDSDYSVIRKT
PTMs - Q9UGN4 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S214 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| Y231 | Phosphorylation | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| Y255 | Phosphorylation | Uniprot | |
| Y267 | Phosphorylation | Uniprot | |
| S269 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot |
Research Backgrounds
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6.
Phosphorylated on tyrosine.
N-glycosylated.
Cell membrane>Single-pass type I membrane protein.
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D.
Belongs to the CD300 family.
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