Tensin-2 Antibody - #DF8623

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Product: Tensin-2 Antibody
Catalog: DF8623
Description: Rabbit polyclonal antibody to Tensin-2
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 152 kD; 153kD(Calculated).
Uniprot: Q63HR2
RRID: AB_2841827

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, IF/ICC 1:100-1:500, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
Tensin-2 Antibody detects endogenous levels of total Tensin-2.
RRID:
AB_2841827
Cite Format: Affinity Biosciences Cat# DF8623, RRID:AB_2841827.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

C1 domain containing phosphatase and tensin homolog; C1 domain-containing phosphatase and tensin homolog; C1 TEN; C1-TEN; C1TEN; DKFZp686D13244; FLJ16320; KIAA1075; TENC 1; TENC1; TENC1_HUMAN; Tensin 2; Tensin like C1 domain containing phosphatase; Tensin-2; Tensin-like C1 domain-containing phosphatase; TNS2;

Immunogens

Immunogen:
Uniprot:

Q63HR2(TNS2_HUMAN) >>Visit HPA database.

Gene(ID):
TNS2(23371)
Expression:
Q63HR2 TNS2_HUMAN:

Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.

Sequence:
MKSSGPVERLLRALGRRDSSRAASRPRKAEPHSFREKVFRKKPPVCAVCKVTIDGTGVSCRVCKVATHRKCEAKVTSACQALPPVELRRNTAPVRRIEHLGSTKSLNHSKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSGSIRMNSSPLFLHYVLIPMLPAFEPGTGFQPFLKIYQSMQLVYTSGVYHIAGPGPQQLCISLEPALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDERFPFQASVEFVFSSSPEKIKGSTPRNDPSVSVDYNTTEPAVRWDSYENFNQHHEDSVDGSLTHTRGPLDGSPYAQVQRPPRQTPPAPSPEPPPPPMLSVSSDSGHSSTLTTEPAAESPGRPPPTAAERQELDRLLGGCGVASGGRGAGRETAILDDEEQPTVGGGPHLGVYPGHRPGLSRHCSCRQGYREPCGVPNGGYYRPEGTLERRRLAYGGYEGSPQGYAEASMEKRRLCRSLSEGLYPYPPEMGKPATGDFGYRAPGYREVVILEDPGLPALYPCPACEEKLALPTAALYGLRLEREAGEGWASEAGKPLLHPVRPGHPLPLLLPACGHHHAPMPDYSCLKPPKAGEEGHEGCSYTMCPEGRYGHPGYPALVTYSYGGAVPSYCPAYGRVPHSCGSPGEGRGYPSPGAHSPRAGSISPGSPPYPQSRKLSYEIPTEEGGDRYPLPGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSAPTQRLSPGEALPPVSQAGTGKAPELPSGSGPEPLAPSPVSPTFPPSSPSDWPQERSPGGHSDGASPRSPVPTTLPGLRHAPWQGPRGPPDSPDGSPLTPVPSQMPWLVASPEPPQSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWGPEQASSPARGISHHVTFAPLLSDNVPQTPEPPTQESQSNVKFVQDTSKFWYKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPVEQLVRHFLIETGPKGVKIKGCPSEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETPEAPVPTNMSTAADLLRQGAACSVLYLTSVETESLTGPQAVARASSAALSCSPRPTPAVVHFKVSAQGITLTDNQRKLFFRRHYPVNSITFSSTDPQDRRWTNPDGTTSKIFGFVAKKPGSPWENVCHLFAELDPDQPAGAIVTFITKVLLGQRK

PTMs - Q63HR2 As Substrate

Site PTM Type Enzyme
S19 Phosphorylation
S20 Phosphorylation
S24 Phosphorylation
S33 Phosphorylation
T56 Phosphorylation
T91 Phosphorylation
S102 Phosphorylation
S118 Phosphorylation
S120 Phosphorylation
T186 Phosphorylation
Y245 Phosphorylation
Y248 Phosphorylation
S249 Phosphorylation
S252 Phosphorylation
S455 Phosphorylation
Y456 Phosphorylation
S466 Phosphorylation
S470 Phosphorylation
T472 Phosphorylation
T474 Phosphorylation
S481 Phosphorylation
Y483 Phosphorylation
T493 Phosphorylation
S498 Phosphorylation
S552 Phosphorylation
T571 Phosphorylation
T615 Phosphorylation
Y623 Phosphorylation
S629 Phosphorylation
Y633 Phosphorylation
S637 Phosphorylation
S646 Phosphorylation
S648 Phosphorylation
Y652 Phosphorylation
Y673 Phosphorylation
Y705 Phosphorylation
S769 Phosphorylation
Y770 Phosphorylation
S811 Phosphorylation
Y818 Phosphorylation
S820 Phosphorylation
S825 Phosphorylation
S830 Phosphorylation
S832 Phosphorylation
S835 Phosphorylation
Y838 Phosphorylation
S845 Phosphorylation
S893 Phosphorylation
S906 Phosphorylation
S909 Phosphorylation
T910 Phosphorylation
T914 Phosphorylation
S915 Phosphorylation
S916 Phosphorylation
T929 Phosphorylation
S931 Phosphorylation
S941 Phosphorylation
S962 Phosphorylation
S964 Phosphorylation
S972 Phosphorylation
S975 Phosphorylation
T977 Phosphorylation
S991 Phosphorylation
S996 Phosphorylation
S1000 Phosphorylation
S1003 Phosphorylation
T1008 Phosphorylation
S1096 Phosphorylation
T1118 Phosphorylation
S1126 Phosphorylation
K1131 Ubiquitination
K1138 Ubiquitination
K1157 Ubiquitination
T1182 Phosphorylation
S1218 Phosphorylation
Y1221 Phosphorylation
S1247 Phosphorylation
S1342 Phosphorylation
T1344 Phosphorylation

Research Backgrounds

Function:

Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin. In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy. Negatively regulates PI3K-AKT pathway activation.

Subcellular Location:

Cell junction>Focal adhesion. Cell membrane>Peripheral membrane protein>Cytoplasmic side.
Note: Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.

Subunit Structure:

Interacts with AXL. Interacts with SYK; leading to its phosphorylation.

Family&Domains:

Belongs to the PTEN phosphatase protein family.

Restrictive clause

 

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For Research Use Only.
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