ADAM19 Antibody - #DF9161
| Product: | ADAM19 Antibody |
| Catalog: | DF9161 |
| Description: | Rabbit polyclonal antibody to ADAM19 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 105kDa; 105kD(Calculated). |
| Uniprot: | Q9H013 |
| RRID: | AB_2842357 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9161, RRID:AB_2842357.
Fold/Unfold
A disintegrin and metalloproteinase domain 19 (meltrin beta); A disintegrin and metalloproteinase domain 19; ADAM 19; ADAM metallopeptidase domain 19; Disintegrin and metalloproteinase domain containing protein 19; FKSG 34; FKSG34; MADDAM; Meltrin beta; Metalloprotease and disintegrin dentritic antigen marker; Metalloprotease disintegrin meltrin beta; MLTN B; MLTNB;
Immunogens
- Q9H013 ADA19_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAPKVSPREALKVKAGTRGLQGGRCRVEKTKQFMLLVVWTELPEQKPRAKHSCFLVPA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H013 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T183 | O-Glycosylation | Uniprot | |
| T191 | O-Glycosylation | Uniprot | |
| T194 | O-Glycosylation | Uniprot | |
| Y248 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| K734 | Ubiquitination | Uniprot | |
| K741 | Ubiquitination | Uniprot | |
| K766 | Ubiquitination | Uniprot | |
| T769 | Phosphorylation | Uniprot | |
| T779 | Phosphorylation | Uniprot | |
| S802 | Phosphorylation | Uniprot | |
| S818 | Phosphorylation | Uniprot | |
| S830 | Phosphorylation | Uniprot | |
| S831 | Phosphorylation | Uniprot | |
| S872 | Phosphorylation | Uniprot | |
| S880 | Phosphorylation | Uniprot | |
| S892 | Phosphorylation | Uniprot | |
| K909 | Ubiquitination | Uniprot | |
| R921 | Methylation | Uniprot |
Research Backgrounds
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
The precursor is cleaved by a furin endopeptidase.
Membrane>Single-pass type I membrane protein.
Expressed in many normal organ tissues and several cancer cell lines.
Interacts with SH3PXD2A.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
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