ADAM30 Antibody - #DF9165
| Product: | ADAM30 Antibody |
| Catalog: | DF9165 |
| Description: | Rabbit polyclonal antibody to ADAM30 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Rabbit |
| Mol.Wt.: | 89 kDa; 89kD(Calculated). |
| Uniprot: | Q9UKF2 |
| RRID: | AB_2842361 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9165, RRID:AB_2842361.
Fold/Unfold
A disintegrin and metallopeptidase domain 30; ADA30_HUMAN; ADAM 30; ADAM metallopeptidase domain 30; ADAM30; Disintegrin and metalloproteinase domain-containing protein 30; EC 3.4.24.-; MGC132801; MGC132802; OTTHUMP00000014034; Svph4;
Immunogens
Expressed in brain neurons (at protein level) (PubMed:27333034). Expressed in testis (PubMed:10512762).
- Q9UKF2 ADA30_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRPKAKSVKKQKK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UKF2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K251 | Acetylation | Uniprot | |
| S685 | Phosphorylation | Uniprot | |
| T746 | Phosphorylation | Uniprot |
Research Backgrounds
Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation.
Late endosome membrane>Single-pass type I membrane protein.
Expressed in brain neurons (at protein level). Expressed in testis.
Interacts with CTSD; this leads to activation of CTSD.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
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