APBA2 Antibody - #DF9203
| Product: | APBA2 Antibody |
| Catalog: | DF9203 |
| Description: | Rabbit polyclonal antibody to APBA2 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 83 kDa; 83kD(Calculated). |
| Uniprot: | Q99767 |
| RRID: | AB_2842399 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9203, RRID:AB_2842399.
Fold/Unfold
Adapter protein X11beta; Amyloid beta A4 precursor protein-binding family A member 2; APBA2; APBA2_HUMAN; D15S1518E; HsT16821; LIN 10; MGC:14091; MGC99508; Mint 2; Mint-2; MINT2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 beta; X11 like protein; X11l;
Immunogens
- Q99767 APBA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEEYLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMTSITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGFKPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q99767 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S8 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| Y186 | Phosphorylation | Uniprot | |
| Y193 | Phosphorylation | Uniprot | |
| Y196 | Phosphorylation | Uniprot | |
| Y197 | Phosphorylation | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| T306 | Phosphorylation | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| S478 | Phosphorylation | Uniprot | |
| S480 | Phosphorylation | Uniprot | |
| S609 | Phosphorylation | Uniprot | |
| S613 | Phosphorylation | Uniprot |
Research Backgrounds
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Brain.
Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid-beta protein, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP.
Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
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