AQP8 Antibody - #DF9224

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Product: AQP8 Antibody
Catalog: DF9224
Description: Rabbit polyclonal antibody to AQP8
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 25~40kDa; 27kD(Calculated).
Uniprot: O94778
RRID: AB_2842420

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
AQP8 Antibody detects endogenous levels of total AQP8.
RRID:
AB_2842420
Cite Format: Affinity Biosciences Cat# DF9224, RRID:AB_2842420.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

AQP 8; AQP-8; AQP8; AQP8_HUMAN; Aquaporin 8; Aquaporin-8; Aquaporin8;

Immunogens

Immunogen:

A synthesized peptide derived from human AQP8, corresponding to a region within N-terminal amino acids.

Uniprot:

O94778(AQP8_HUMAN) >>Visit HPA database.

Gene(ID):
AQP8(343)
Expression:
O94778 AQP8_HUMAN:

Detected in the sperm midpiece (at protein level) (PubMed:28042826). Expressed only in pancreas and colon.

Sequence:
MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR

PTMs - O94778 As Substrate

Site PTM Type Enzyme
S21 Phosphorylation

Research Backgrounds

Function:

Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.

Subcellular Location:

Mitochondrion membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Detected in the sperm midpiece (at protein level). Expressed only in pancreas and colon.

Family&Domains:

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Belongs to the MIP/aquaporin (TC 1.A.8) family.

References

1). Tanshinone IIA increased amniotic fluid volume through down-regulating placental AQPs expression via inhibiting the activity of GSK-3β. CELL AND TISSUE RESEARCH, 2022 (PubMed: 35674921) [IF=3.2]

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Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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