GPHN Antibody - #DF9531
| Product: | GPHN Antibody |
| Catalog: | DF9531 |
| Description: | Rabbit polyclonal antibody to GPHN |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 80 kDa; 80kD(Calculated). |
| Uniprot: | Q9NQX3 |
| RRID: | AB_2842727 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9531, RRID:AB_2842727.
Fold/Unfold
Domain E; Domain G; GEPH; GEPH_HUMAN; GPH; GPHN; GPHRYN; KIAA1385; Molybdopterin molybdenumtransferase; MPT adenylyltransferase; MPT Mo-transferase;
Immunogens
- Q9NQX3 GEPH_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAAIAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NQX3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R34 | Methylation | Uniprot | |
| T52 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| T96 | Phosphorylation | Uniprot | |
| T100 | Phosphorylation | Uniprot | |
| T139 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| T198 | Phosphorylation | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| S200 | Phosphorylation | Uniprot | |
| S230 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| T265 | Phosphorylation | Uniprot | |
| T266 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| S270 | Phosphorylation | P06493 (CDK1) , Q00535 (CDK5) , P49841 (GSK3B) | Uniprot |
| T276 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| T281 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| S319 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| T402 | Phosphorylation | Uniprot | |
| S480 | Phosphorylation | Uniprot | |
| T570 | Phosphorylation | Uniprot | |
| S571 | Phosphorylation | Uniprot | |
| S575 | Phosphorylation | Uniprot | |
| T655 | Phosphorylation | Uniprot |
Research Backgrounds
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Cell junction>Synapse. Cell junction>Synapse>Postsynaptic cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cell projection>Dendrite. Cell junction>Synapse>Postsynaptic density.
Note: Cytoplasmic face of glycinergic postsynaptic membranes.
Homotrimer, homodimer and homooligomer. Interacts with GABARAP (By similarity). Interacts with SRGAP2 (via SH3 domain) (By similarity). Interacts with GABRA3. Interacts with GLRB. GABRA3 and GLRB occupy overlapping binding sites (By similarity). Interacts with ARHGAP32; IQSEC3, INSYN1 and INSYN2A (By similarity).
In the N-terminal section; belongs to the MoaB/Mog family.
In the C-terminal section; belongs to the MoeA family.
Research Fields
· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > GABAergic synapse.
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