Product: GPHN Antibody
Catalog: DF9531
Source: Rabbit
Application: WB, IHC, ELISA(peptide)
Reactivity: Human, Mouse
Prediction: Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 80 kD; 80kD(Calculated).
Uniprot: Q9NQX3
RRID: AB_2842727

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Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
Reactivity:
Human,Mouse
Prediction:
Pig(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
GPHN Antibody detects endogenous levels of total GPHN.
RRID:
AB_2842727
Cite Format: Affinity Biosciences Cat# DF9531, RRID:AB_2842727.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Domain E; Domain G; GEPH; GEPH_HUMAN; GPH; GPHN; GPHRYN; KIAA1385; Molybdopterin molybdenumtransferase; MPT adenylyltransferase; MPT Mo-transferase;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Sequence:
MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAAIAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Bovine
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9NQX3 As Substrate

Site PTM Type Enzyme
R34 Methylation
T52 Phosphorylation
S54 Phosphorylation
K57 Ubiquitination
T96 Phosphorylation
T100 Phosphorylation
T139 Phosphorylation
S147 Phosphorylation
S188 Phosphorylation
S194 Phosphorylation
T198 Phosphorylation
T199 Phosphorylation
S200 Phosphorylation
S230 Phosphorylation
S250 Phosphorylation
T265 Phosphorylation
T266 Phosphorylation
S268 Phosphorylation
S270 Phosphorylation P06493 (CDK1) , Q00535 (CDK5) , P49841 (GSK3B)
T276 Phosphorylation
S277 Phosphorylation
S280 Phosphorylation
T281 Phosphorylation
S283 Phosphorylation
T286 Phosphorylation
S291 Phosphorylation
S294 Phosphorylation
S295 Phosphorylation
K296 Ubiquitination
S303 Phosphorylation
S305 Phosphorylation
S319 Phosphorylation
S371 Phosphorylation
S393 Phosphorylation
T402 Phosphorylation
S480 Phosphorylation
T570 Phosphorylation
S571 Phosphorylation
S575 Phosphorylation
T655 Phosphorylation

Research Backgrounds

Function:

Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.

Subcellular Location:

Cell junction>Synapse. Cell junction>Synapse>Postsynaptic cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cell projection>Dendrite. Cell junction>Synapse>Postsynaptic density.
Note: Cytoplasmic face of glycinergic postsynaptic membranes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Homotrimer, homodimer and homooligomer. Interacts with GABARAP (By similarity). Interacts with SRGAP2 (via SH3 domain) (By similarity). Interacts with GABRA3. Interacts with GLRB. GABRA3 and GLRB occupy overlapping binding sites (By similarity). Interacts with ARHGAP32; IQSEC3, INSYN1 and INSYN2A (By similarity).

Family&Domains:

In the N-terminal section; belongs to the MoaB/Mog family.

In the C-terminal section; belongs to the MoeA family.

Research Fields

· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > GABAergic synapse.

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