Product: SLC9A5 Antibody
Catalog: DF9938
Source: Rabbit
Application: WB, ELISA(peptide)
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 99 kD; 99kD(Calculated).
Uniprot: Q14940
RRID: AB_2843132

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Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(92%), Horse(100%), Sheep(92%), Rabbit(83%), Dog(92%)
Clonality:
Polyclonal
Specificity:
SLC9A5 Antibody detects endogenous levels of total SLC9A5.
RRID:
AB_2843132
Cite Format: Affinity Biosciences Cat# DF9938, RRID:AB_2843132.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Gm696; Na(+)/H(+) exchanger 5; NHE-5; NHE5; SL9A5_HUMAN; Slc9a5; Sodium/hydrogen exchanger 5; solute carrier family 9 (sodium/hydrogen exchanger), isoform 5; Solute carrier family 9 (sodium/hydrogen exchanger), member 5; Solute carrier family 9 member 5;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q14940 SL9A5_HUMAN:

Expressed in brain, testis, spleen, and skeletal muscle.

Sequence:
MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTVESEEEEEESDSSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
92
Sheep
92
Dog
92
Rabbit
83
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q14940 As Substrate

Site PTM Type Enzyme
S321 Phosphorylation
K459 Ubiquitination
S538 Phosphorylation
S559 Phosphorylation
S575 Phosphorylation
S577 Phosphorylation
S618 Phosphorylation
S620 Phosphorylation
T681 Phosphorylation
S702 Phosphorylation P25098 (GRK2) , P68400 (CSNK2A1)
S709 Phosphorylation P68400 (CSNK2A1) , P25098 (GRK2)
S711 Phosphorylation P68400 (CSNK2A1) , P25098 (GRK2)
S712 Phosphorylation P25098 (GRK2) , P68400 (CSNK2A1)
T714 Phosphorylation P68400 (CSNK2A1) , P25098 (GRK2)
T729 Phosphorylation
S741 Phosphorylation
S747 Phosphorylation
S851 Phosphorylation
S853 Phosphorylation
S855 Phosphorylation
S856 Phosphorylation

Research Backgrounds

Function:

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).

PTMs:

Phosphorylated (Possible).

Subcellular Location:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in brain, testis, spleen, and skeletal muscle.

Subunit Structure:

Interacts with CHP1 and CHP2 (By similarity). Interacts with ARRB2.

Family&Domains:

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Restrictive clause

 

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