A-Myb Antibody - #AF9007
| Product: | A-Myb Antibody |
| Catalog: | AF9007 |
| Description: | Rabbit polyclonal antibody to A-Myb |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 85kDa; 86kD(Calculated). |
| Uniprot: | P10243 |
| RRID: | AB_2843198 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF9007, RRID:AB_2843198.
Fold/Unfold
A-Myb; AMYB; MGC120059; MGC120061; Myb related protein A; Myb-like protein 1; Myb-related protein A; MYBA_HUMAN; MYBL1;
Immunogens
- P10243 MYBA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISDMQSENRFTTSLLMIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPNTSKVVKLEKNLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P10243 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K79 | Ubiquitination | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| K138 | Sumoylation | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K394 | Acetylation | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| T442 | Phosphorylation | Uniprot | |
| S458 | Phosphorylation | Uniprot | |
| T479 | Phosphorylation | Uniprot | |
| T541 | Phosphorylation | Uniprot | |
| T551 | Phosphorylation | Uniprot | |
| T552 | Phosphorylation | Uniprot | |
| T555 | Phosphorylation | Uniprot | |
| T557 | Phosphorylation | Uniprot | |
| K602 | Sumoylation | Uniprot | |
| K621 | Acetylation | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| S683 | Phosphorylation | Uniprot | |
| K686 | Ubiquitination | Uniprot | |
| K704 | Acetylation | Uniprot | |
| S745 | Phosphorylation | Uniprot |
Research Backgrounds
Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity).
Nucleus.
Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
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