Product: CTNNAL1 Antibody
Catalog: AF7592
Description: Rabbit polyclonal antibody to CTNNAL1
Application: WB
Reactivity: Human
Prediction: Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 82kDa; 82kD(Calculated).
Uniprot: Q9UBT7
RRID: AB_2843956

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Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
CTNNAL1 Antibody detects endogenous levels of total CTNNAL1.
RRID:
AB_2843956
Cite Format: Affinity Biosciences Cat# AF7592, RRID:AB_2843956.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ACRP; Alpha catenin related protein; alpha CATU; Alpha catulin; Alpha-catenin-related protein; Alpha-catulin; alpha2 catulin; catenin (cadherin associated protein), alpha like 1; Catenin alpha like protein 1; Catenin alpha-like protein 1; catenin, alpha like 1; CLLP; CTNL1_HUMAN; CTNNAL1; Highly similar to ALPHA CATENIN;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q9UBT7 CTNL1_HUMAN:

Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland.

Sequence:
MAASPGPAGVGGAGAVYGSGSSGFALDSGLEIKTRSVEQTLLPLVSQITTLINHKDNTKKSDKTLQAIQRVGQAVNLAVGRFVKVGEAIANENWDLKEEINIACIEAKQAGETIAALTDITNLNHLESDGQITIFTDKTGVIKAARLLLSSVTKVLLLADRVVIKQIITSRNKVLATMERLEKVNSFQEFVQIFSQFGNEMVEFAHLSGDRQNDLKDEKKKAKMAAARAVLEKCTMMLLTASKTCLRHPNCESAHKNKEGVFDRMKVALDKVIEIVTDCKPNGETDISSISIFTGIKEFKMNIEALRENLYFQSKENLSVTLEVILERMEDFTDSAYTSHEHRERILELSTQARMELQQLISVWIQAQSKKTKSIAEELELSILKISHSLNELKKELHSTATQLAADLLKYHADHVVLKALKLTGVEGNLEALAEYACKLSEQKEQLVETCRLLRHISGTEPLEITCIHAEETFQVTGQQIISAAETLTLHPSSKIAKENLDVFCEAWESQISDMSTLLREINDVFEGRRGEKYGYLSLPKPMKNNANLKSLKPDKPDSEEQAKIAKLGLKLGLLTSDADCEIEKWEDQENEIVQYGRNMSSMAYSLYLFTRGEGPLKTSQDLIHQLEVFAAEGLKLTSSVQAFSKQLKDDDKLMLLLEINKLIPLCHQLQTVTKTSLQNKVFLKVDKCITKTRSMMALLVQLLSLCYKLLKKLQMENNGWVSVTNKDTMDSKT

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Chicken
71
Xenopus
57
Pig
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9UBT7 As Substrate

Site PTM Type Enzyme
T40 Phosphorylation
S61 Phosphorylation
K84 Ubiquitination
K154 Ubiquitination
R161 Methylation
T240 Phosphorylation
S242 Phosphorylation
K258 Ubiquitination
K315 Acetylation
K373 Ubiquitination
S374 Phosphorylation
K394 Ubiquitination
K419 Ubiquitination
Y436 Phosphorylation
K439 Ubiquitination
K444 Ubiquitination
Y534 Phosphorylation
Y536 Phosphorylation
S538 Phosphorylation
S640 Phosphorylation
K681 Ubiquitination

Research Backgrounds

Function:

May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).

Subcellular Location:

Cytoplasm>Cytoskeleton. Cell membrane>Peripheral membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland.

Subunit Structure:

Interacts with ARHGEF1.

Family&Domains:

Belongs to the vinculin/alpha-catenin family.

Restrictive clause

 

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