ARL13B Antibody - #DF12000
| Product: | ARL13B Antibody |
| Catalog: | DF12000 |
| Description: | Rabbit polyclonal antibody to ARL13B |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat, Dog |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 40-48 kDa, 66 kDa; 49kD(Calculated). |
| Uniprot: | Q3SXY8 |
| RRID: | AB_2844805 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12000, RRID:AB_2844805.
Fold/Unfold
ADP ribosylation factor like 13B; ADP ribosylation factor like 2 like 1; ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 2-like 1; AR13B_HUMAN; arl13b; ARL2-like protein 1; ARL2L1; JBTS8;
Immunogens
- Q3SXY8 AR13B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVLANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAISGYGKKIDKSIKKGLYWLLHVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVPQRPNSDAHDVIS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q3SXY8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| Y320 | Phosphorylation | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| T385 | Phosphorylation | Uniprot | |
| Y406 | Phosphorylation | Uniprot |
Research Backgrounds
Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidence is required to confirm these data.
Sumoylation is required for PKD2 entry into cilium.
Cell projection>Cilium membrane>Lipid-anchor. Cell projection>Cilium.
Note: Associates to the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone.
Expressed in the developing brain.
Monomer (By similarity). Interacts with PIFO. Interacts with IFT complex B components IFT46 and IFT74.
Belongs to the small GTPase superfamily. Arf family.
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