Choline kinase alpha Antibody - #DF12067
| Product: | Choline kinase alpha Antibody |
| Catalog: | DF12067 |
| Description: | Rabbit polyclonal antibody to Choline kinase alpha |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| Mol.Wt.: | 50 kDa,52 kDa; 52kD(Calculated). |
| Uniprot: | P35790 |
| RRID: | AB_2844872 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12067, RRID:AB_2844872.
Fold/Unfold
CHETK alpha; CHETK-alpha; CHK; CHKA; CK; CKI; EK; Ethanolamine kinase; Choline kinase alpha;
Immunogens
- P35790 CHKA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P35790 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K96 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| Y197 | Phosphorylation | P12931 (SRC) | Uniprot |
| K247 | Acetylation | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| Y333 | Phosphorylation | P12931 (SRC) | Uniprot |
| T371 | Phosphorylation | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| Y437 | Phosphorylation | Uniprot | |
| Y440 | Phosphorylation | Uniprot |
Research Backgrounds
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
Cytoplasm.
Heterodimer with CHKB (By similarity). Homodimer.
Belongs to the choline/ethanolamine kinase family.
Research Fields
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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