PHF17 Antibody - #DF12451
| Product: | PHF17 Antibody |
| Catalog: | DF12451 |
| Description: | Rabbit polyclonal antibody to PHF17 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Sheep, Rabbit, Dog |
| Mol.Wt.: | 58-61 kDa,94-96 kDa, 70 kDa; 96kD(Calculated). |
| Uniprot: | Q6IE81 |
| RRID: | AB_2845256 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12451, RRID:AB_2845256.
Fold/Unfold
FLJ22479; Gene for apoptosis and differentiation in epithelia; JADE1; JADE1_HUMAN; KIAA1807; OTTHUMP00000219842; OTTHUMP00000219934; OTTHUMP00000219935; OTTHUMP00000219936; PHD finger protein 17; PHD protein Jade 1; Phf17; Protein Jade 1; Protein Jade-1;
Immunogens
Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
- Q6IE81 JADE1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKGDLKDKSFKQSHKPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLIKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACHQHSDYPYLGLGRVPAKERAKSKLKSDNENDGYVPDVEMSDSESEASEKKCIHTSSTISRRTDIIRRSILAS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6IE81 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S8 | Phosphorylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| S20 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| K82 | Ubiquitination | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| T92 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K114 | Sumoylation | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| K302 | Acetylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| K380 | Acetylation | Uniprot | |
| S392 | Phosphorylation | Uniprot | |
| T468 | Phosphorylation | Uniprot | |
| K470 | Acetylation | Uniprot | |
| R501 | Methylation | Uniprot | |
| R503 | Methylation | Uniprot | |
| K532 | Ubiquitination | Uniprot | |
| S590 | Phosphorylation | Uniprot | |
| S603 | Phosphorylation | Uniprot | |
| S606 | Phosphorylation | Uniprot | |
| T610 | Phosphorylation | Uniprot | |
| T702 | Phosphorylation | Uniprot | |
| S703 | Phosphorylation | Uniprot | |
| S709 | Phosphorylation | Uniprot | |
| T713 | Phosphorylation | Uniprot | |
| T739 | Phosphorylation | Uniprot | |
| T740 | Phosphorylation | Uniprot | |
| S743 | Phosphorylation | Uniprot | |
| S796 | Phosphorylation | Uniprot | |
| Y803 | Phosphorylation | Uniprot | |
| S810 | Phosphorylation | Uniprot | |
| S812 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
Cytoplasm. Nucleus. Cytoplasm>Cytoskeleton>Cilium basal body.
Note: Localizes to the ciliary transition zone.
Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5. Interacts with NPHP4.
The 2 PHD-type zinc fingers are required for transcriptional activity.
Belongs to the JADE family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.