TBCE Antibody - #DF12766

(3)  
Product: TBCE Antibody
Catalog: DF12766
Description: Rabbit polyclonal antibody to TBCE
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat, Monkey
Prediction: Pig, Zebrafish, Bovine, Sheep, Rabbit, Dog, Xenopus
Mol.Wt.: 59 kDa; 59kD(Calculated).
Uniprot: Q15813
RRID: AB_2845727

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat,Monkey
Prediction:
Pig(100%), Zebrafish(91%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(92%), Xenopus(82%)
Clonality:
Polyclonal
Specificity:
TBCE Antibody detects endogenous levels of total TBCE.
RRID:
AB_2845727
Cite Format: Affinity Biosciences Cat# DF12766, RRID:AB_2845727.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HRD; KCS; KCS1; Pac2; tbce; TBCE_HUMAN; Tubulin specific chaperone e; Tubulin-folding cofactor E; Tubulin-specific chaperone E;

Immunogens

Immunogen:
Uniprot:

Q15813(TBCE_HUMAN) >>Visit HPA database.

Gene(ID):
TBCE(6905)
Sequence:
MSDTLTADVIGRRVEVNGEHATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGSFIRPNKVNFGTDFLTAIKNRYVLEDGPEEDRKEQIVTIGNKPVETIGFDSIMKQQSQLSKLQEVSLRNCAVSCAGEKGGVAEACPNIRKVDLSKNLLSSWDEVIHIADQLRHLEVLNVSENKLKFPSGSVLTGTLSVLKVLVLNQTGITWAEVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSNQLIDENQLYLIAHLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLTKEDKEAETARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLKNQLLTLKIKYPHQLDQKVLEKQLPGSMTIQKVKGLLSRLLKVPVSDLLLSYESPKKPGREIELENDLKSLQFYSVENGDCLLVRW

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Rabbit
100
Dog
92
Zebrafish
91
Xenopus
82
Chicken
73
Horse
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q15813 As Substrate

Site PTM Type Enzyme
S2 Acetylation
S2 Phosphorylation
T4 Phosphorylation
T6 Phosphorylation
K48 Ubiquitination
K60 Ubiquitination
K86 Ubiquitination
K109 Ubiquitination
K121 Ubiquitination
S124 Phosphorylation
S127 Phosphorylation
K128 Ubiquitination
S133 Phosphorylation
K145 Ubiquitination
K192 Ubiquitination
S195 Phosphorylation
T200 Phosphorylation
S204 Phosphorylation
K346 Ubiquitination
K370 Ubiquitination
K387 Ubiquitination
K394 Ubiquitination
S408 Phosphorylation
K434 Ubiquitination
K442 Ubiquitination
K451 Acetylation
K451 Ubiquitination
K459 Ubiquitination
K463 Acetylation
K463 Ubiquitination
S479 Phosphorylation
S487 Phosphorylation
S495 Phosphorylation P24941 (CDK2)

Research Backgrounds

Function:

Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.

Subcellular Location:

Cytoplasm. Cytoplasm>Cytoskeleton.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers (By similarity). Interacts with TBCD.

Family&Domains:

Belongs to the TBCE family.

Restrictive clause

 

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