CAPRIN2 Antibody - #DF12877
Product: | CAPRIN2 Antibody |
Catalog: | DF12877 |
Description: | Rabbit polyclonal antibody to CAPRIN2 |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
Mol.Wt.: | 126 kDa; 126kD(Calculated). |
Uniprot: | Q6IMN6 |
RRID: | AB_2845838 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12877, RRID:AB_2845838.
Fold/Unfold
C1q domain-containing protein 1; C1QDC1; CAPR2_HUMAN; Caprin family member 2; Caprin-2; caprin2; Cytoplasmic activation/proliferation-associated protein 2; EEG 1; EEG1; Gastric cancer multidrug resistance-associated protein; KIAA1873; Protein EEG-1; RNA granule protein 140; RNG140;
Immunogens
Detected in all tissues tested with highest levels of expression in brain and spleen.
- Q6IMN6 CAPR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEVQVSQASLGFELTSVEKSLREWSRLSREVIAWLCPSSPNFILNFPPPPSASSVSMVQLFSSPFGYQSPSGHSEEEREGNMKSAKPQVNHSQHGESQRALSPLQSTLSSAASPSQAYETYIENGLICLKHKIRNIEKKKLKLEDYKDRLKSGEHLNPDQLEAVEKYEEVLHNLEFAKELQKTFSGLSLDLLKAQKKAQRREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSSLYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKTQLSKTESVKESESLMEFAQPEIQPQEFLNRRYMTEVDYSNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSWTTPMCEEQDSKQPETPKSWENNVESQKHSLTSQSQISPKSWGVATASLIPNDQLLPRKLNTEPKDVPKPVHQPVGSSSTLPKDPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIPPGKQPSSLASPNPPMAKGSEQGFQSPPASSSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVHSQETAANYHPDGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYKGFDTYRGLPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNSGDSGQGDSRSMTPVDVPVTNPAATILPVHVYPLPQQMRVAFSAARTSNLAPGTLDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVPLYVNLMKNEEVLVSAYANDGAPDHETASNHAILQLFQGDQIWLRLHRGAIYGSSWKYSTFSGYLLYQD
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6IMN6 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
Y146 | Phosphorylation | Uniprot | |
Y253 | Phosphorylation | Uniprot | |
Y394 | Phosphorylation | Uniprot | |
Y483 | Phosphorylation | Uniprot | |
S547 | Phosphorylation | Uniprot | |
S554 | Phosphorylation | Uniprot | |
T560 | Phosphorylation | Uniprot | |
S566 | Phosphorylation | Uniprot | |
S739 | Phosphorylation | Uniprot | |
S749 | Phosphorylation | Uniprot | |
S750 | Phosphorylation | Uniprot | |
S751 | Phosphorylation | Uniprot | |
R877 | Methylation | Uniprot | |
K883 | Acetylation | Uniprot | |
R889 | Methylation | Uniprot | |
Y899 | Phosphorylation | Uniprot | |
Y909 | Phosphorylation | Uniprot | |
Y914 | Phosphorylation | Uniprot | |
Y924 | Phosphorylation | Uniprot | |
T956 | Phosphorylation | Uniprot | |
S959 | Phosphorylation | Uniprot | |
S962 | Phosphorylation | Uniprot | |
S967 | Phosphorylation | Uniprot |
Research Backgrounds
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.
Cytoplasm.
Mitochondrion. Cytoplasm.
Note: Expressed throughout the cytoplasm.
Mitochondrion.
Note: Colocalizes with aggregated mitochondria.
Cell membrane>Peripheral membrane protein.
Detected in all tissues tested with highest levels of expression in brain and spleen.
Homotrimer; via C1q domain. Found in a complex with LRP6, CCNY and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus. Interacts with LRP5. Interacts with LRP6.
The C1q domain is essential for the function in Wnt signaling.
Belongs to the caprin family.
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