CCM2 Antibody - #DF12886
| Product: | CCM2 Antibody |
| Catalog: | DF12886 |
| Description: | Rabbit polyclonal antibody to CCM2 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 52 kDa; 49kD(Calculated). |
| Uniprot: | Q9BSQ5 |
| RRID: | AB_2845847 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12886, RRID:AB_2845847.
Fold/Unfold
C7orf22; Ccm2; CCM2 gene; CCM2_HUMAN; Cerebral cavernous malformation 2; Cerebral cavernous malformations 2 protein; Chromosome 7 open reading frame 22; Malcavernin; MGC4067; MGC4607; MGC74868; OSM; Osmosensing scaffold for MEKK3; OTTHUMP00000159554; OTTHUMP00000214270; OTTHUMP00000214271; OTTHUMP00000214273; PP10187;
Immunogens
- Q9BSQ5 CCM2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BSQ5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K6 | Acetylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| Y69 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| T239 | Phosphorylation | Uniprot | |
| T241 | Phosphorylation | Uniprot | |
| S248 | Phosphorylation | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | O00506 (STK25) | Uniprot |
| S393 | Phosphorylation | Uniprot | |
| T394 | Phosphorylation | Uniprot | |
| S396 | Phosphorylation | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| S398 | Phosphorylation | Uniprot | |
| S416 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
Cytoplasm.
Part of a complex with MAP2K3, MAP3K3 and RAC1. Binds RAC1 directly and independently of its nucleotide-bound state (By similarity). Interacts with HEG1 and KRIT1; KRIT1 greatly facilitates the interaction with HEG1 (By similarity). Interacts with PDCD10.
The C-terminal region constitutes an independently folded domain that has structural similarity with the USH1C (harmonin) N-terminus, despite very low sequence similarity.
Belongs to the CCM2 family.
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