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  • Product Name
    Prealbumin antibody
  • Catalog No.
    BF0713
  • RRID
    AB_2846204
  • Source
    Mouse
  • Application
    WB,IHC
  • Reactivity
    Human
  • UniProt
  • Mol.Wt
    16kD;
    16kDa(Calculated).
  • Concentration
    1mg/ml
  • Browse similar products>>

Product Information

Alternative Names:Expand▼

Amyloid;Amyloidosis I;ATTR;Carpal tunnel syndrome 1;CTS;Prealbumin;Transthyretin;Prealbumin;TTR

Applications:

WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.

Reactivity:

Human

Source:

Mouse

Clonality:

Monoclonal

Clone Number:

AFB17792

Purification:

Affinity-chromatography.

Specificity:

Prealbumin mouse monoclonal antibody detects endogenous levels of Prealbumin

RRID:

AB_2846204
Please cite this product as: Affinity Biosciences Cat# BF0713, RRID:AB_2846204.

Format:

Liquid

Concentration:

1mg/ml

Storage Condition and Buffer:

Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Immunogen Information

Immunogen:

A synthetic peptide

Uniprot:



>>Visit The Human Protein Atlas

Gene ID:

Gene Name:

TTR

Molecular Weight:

Observed Mol.Wt.: 16kD.
Predicted Mol.Wt.: 16kDa(Calculated)..

Tissue Specificity:

P02766 TTHY_HUMAN:
Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.

Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

Research Background

Function:

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Post-translational Modifications:

Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.

Subcellular Location:

Secreted. Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte

Tissue Specificity:

Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.

Subunit Structure:

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.

Similarity:

Each monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel.

Belongs to the transthyretin family.

Research Fields

Research Fields:

· Organismal Systems > Endocrine system > Thyroid hormone synthesis.

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Catalog Number :

BF0713-BP
(Blocking peptide available as BF0713-BP)

Price/Size :

$350/1mg.
Tips: For phospho antibody, we provide phospho peptide(0.5mg) and non-phospho peptide(0.5mg).

Function :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

Format and storage :

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Precautions :

This product is for research use only. Not for use in diagnostic or therapeutic procedures.

P02766 as Substrate
Site PTM Type Enzyme
C10 S-Nitrosylation
T23 Phosphorylation
T25 Phosphorylation
S72 Phosphorylation
N118 N-Glycosylation
Y125 Phosphorylation
S137 Phosphorylation
T138 Phosphorylation
IMPORTANT: For western blots, incubate membrane with diluted antibody in 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking, overnight.

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