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$280 100ul
$350 200ul

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  • Product Name
    LYRIC Antibody
  • Catalog No.
    DF13437
  • RRID
    AB_2846456
  • Source
    Rabbit
  • Application
    WB,IHC,ELISA(peptide)
  • Reactivity
    Human, Mouse, Rat
  • Prediction
    Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(86%), Dog(88%), Chicken(88%)
  • UniProt
  • Mol.Wt
    63kD;
    64kDa(Calculated).
  • Concentration
    1mg/ml
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Product Information

Alternative Names:Expand▼

3D3; 3D3/LYRIC; AEG 1; AEG-1; AEG1; Astrocyte elevated gene 1; Astrocyte elevated gene-1 protein; LYRIC; LYRIC/3D3; LYRIC_HUMAN; Lysine rich CEACAM1 associated protein; Lysine rich CEACAM1 co isolated protein; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein; MTDH; Protein LYRIC;

Applications:

WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.

Reactivity:

Human, Mouse, Rat

Predicted Reactivity:

Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(86%), Dog(88%), Chicken(88%)

Source:

Rabbit

Clonality:

Polyclonal

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Specificity:

LYRIC Antibody detects endogenous levels of total LYRIC.

RRID:

AB_2846456
Please cite this product as: Affinity Biosciences Cat# DF13437, RRID:AB_2846456.

Format:

Liquid

Concentration:

1mg/ml

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Immunogen Information

Immunogen:

A synthesized peptide derived from human LYRIC, corresponding to a region within C-terminal amino acids.

Uniprot:



>>Visit The Human Protein Atlas

Gene ID:

Gene Name:

MTDH

Molecular Weight:

Observed Mol.Wt.: 63kD.
Predicted Mol.Wt.: 64kDa(Calculated)..

Tissue Specificity:

Q86UE4 LYRIC_HUMAN:
Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.

Sequence:
MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET

Research Background

Function:

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Subcellular Location:

Endoplasmic reticulum membrane>Single-pass membrane protein. Nucleus membrane>Single-pass membrane protein. Cell junction>Tight junction. Nucleus>Nucleolus. Cytoplasm>Perinuclear region.
Note: In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte

Tissue Specificity:

Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.

Subunit Structure:

Interacts with BCCIP, CREBBP/CBP and RELA/p65.

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Catalog Number :

DF13437-BP
(Blocking peptide available as DF13437-BP)

Price/Size :

$350/1mg.
Tips: For phospho antibody, we provide phospho peptide(0.5mg) and non-phospho peptide(0.5mg).

Function :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

Format and storage :

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Precautions :

This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Pig
100%
Horse
100%
Bovine
100%
Sheep
100%
Dog
88%
Chicken
88%
Rabbit
86%
Xenopus
71%
Zebrafish
0%
High similarity Medium similarity Low similarity No similarity
Q86UE4 as Substrate
Site PTM Type Enzyme
S84 Phosphorylation
K88 Ubiquitination
K107 Ubiquitination
S111 Phosphorylation
K121 Ubiquitination
K125 Ubiquitination
K127 Ubiquitination
T143 Phosphorylation
S146 Phosphorylation
T148 Phosphorylation
K150 Ubiquitination
K170 Acetylation
K174 Acetylation
K174 Ubiquitination
S179 Phosphorylation
S180 Phosphorylation
K185 Ubiquitination
K195 Ubiquitination
S197 Phosphorylation
S214 Phosphorylation
S216 Phosphorylation
S219 Phosphorylation
K248 Ubiquitination
S251 Phosphorylation
S258 Phosphorylation
K261 Methylation
K264 Methylation
S267 Phosphorylation
T268 Phosphorylation
S272 Phosphorylation
S273 Phosphorylation
T280 Phosphorylation
K289 Ubiquitination
K292 Ubiquitination
S294 Phosphorylation
S295 Phosphorylation
S298 Phosphorylation
K303 Ubiquitination
S306 Phosphorylation
S308 Phosphorylation
S311 Phosphorylation
K314 Acetylation
K314 Methylation
K314 Ubiquitination
S323 Phosphorylation
K334 Ubiquitination
R338 Methylation
S339 Phosphorylation
S341 Phosphorylation
S344 Phosphorylation
S347 Phosphorylation
S357 Phosphorylation
T361 Phosphorylation
S362 Phosphorylation
Y364 Phosphorylation
S369 Phosphorylation
S411 Phosphorylation
S415 Phosphorylation
S426 Phosphorylation
T439 Phosphorylation
K441 Acetylation
S457 Phosphorylation
T458 Phosphorylation
T462 Phosphorylation
S478 Phosphorylation
K491 Methylation
K491 Ubiquitination
T492 Phosphorylation
S494 Phosphorylation
T495 Phosphorylation
S496 Phosphorylation
S506 Phosphorylation
K510 Ubiquitination
T511 Phosphorylation
S521 Phosphorylation
S527 Phosphorylation
S529 Phosphorylation
S532 Phosphorylation
S534 Phosphorylation
S546 Phosphorylation
S548 Phosphorylation
T550 Phosphorylation
S558 Phosphorylation
T560 Phosphorylation
S562 Phosphorylation
T564 Phosphorylation
S565 Phosphorylation
S568 Phosphorylation
K570 Ubiquitination
T582 Phosphorylation
IMPORTANT: For western blots, incubate membrane with diluted antibody in 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking, overnight.

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