p90 Autoantigen Antibody - #DF13505
Product: | p90 Autoantigen Antibody |
Catalog: | DF13505 |
Description: | Rabbit polyclonal antibody to p90 Autoantigen |
Application: | WB |
Reactivity: | Human, Monkey |
Mol.Wt.: | 102kDa; 102kD(Calculated). |
Uniprot: | Q8TCG1 |
RRID: | AB_2846524 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13505, RRID:AB_2846524.
Fold/Unfold
Cancerous inhibitor of PP2A; Cancerous Inhibitor of Protein Phosphatase 2A; CIP2A; CIP2A_HUMAN; FLJ12850; Kiaa1524; MGC163436; p90; p90 autoantigen; Protein CIP2A;
Immunogens
Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).
- Q8TCG1 CIP2A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSTACLKSLLLTVSQYKAVKSEANATQLLRHLEVISGQKLTRLFTSNQILTSECLSCLVELLEDPNISASLILSIIGLLSQLAVDIETRDCLQNTYNLNSVLAGVVCRSSHTDSVFLQCIQLLQKLTYNVKIFYSGANIDELITFLIDHIQSSEDELKMPCLGLLANLCRHNLSVQTHIKTLSNVKSFYRTLITLLAHSSLTVVVFALSILSSLTLNEEVGEKLFHARNIHQTFQLIFNILINGDGTLTRKYSVDLLMDLLKNPKIADYLTRYEHFSSCLHQVLGLLNGKDPDSSSKVLELLLAFCSVTQLRHMLTQMMFEQSPPGSATLGSHTKCLEPTVALLRWLSQPLDGSENCSVLALELFKEIFEDVIDAANCSSADRFVTLLLPTILDQLQFTEQNLDEALTRKKCERIAKAIEVLLTLCGDDTLKMHIAKILTTVKCTTLIEQQFTYGKIDLGFGTKVADSELCKLAADVILKTLDLINKLKPLVPGMEVSFYKILQDPRLITPLAFALTSDNREQVQSGLRILLEAAPLPDFPALVLGESIAANNAYRQQETEHIPRKMPWQSSNHSFPTSIKCLTPHLKDGVPGLNIEELIEKLQSGMVVKDQICDVRISDIMDVYEMKLSTLASKESRLQDLLETKALALAQADRLIAQHRCQRTQAETEARTLASMLREVERKNEELSVLLKAQQVESERAQSDIEHLFQHNRKLESVAEEHEILTKSYMELLQRNESTEKKNKDLQITCDSLNKQIETVKKLNESLKEQNEKSIAQLIEKEEQRKEVQNQLVDREHKLANLHQKTKVQEEKIKTLQKEREDKEETIDILRKELSRTEQIRKELSIKASSLEVQKAQLEGRLEEKESLVKLQQEELNKHSHMIAMIHSLSGGKINPETVNLSI
PTMs - Q8TCG1 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
M1 | Acetylation | Uniprot | |
K8 | Ubiquitination | Uniprot | |
Y17 | Phosphorylation | Uniprot | |
K18 | Ubiquitination | Uniprot | |
K21 | Ubiquitination | Uniprot | |
K40 | Acetylation | Uniprot | |
K40 | Ubiquitination | Uniprot | |
C92 | S-Nitrosylation | Uniprot | |
C108 | S-Nitrosylation | Uniprot | |
T234 | Phosphorylation | Uniprot | |
T248 | Phosphorylation | Uniprot | |
T250 | Phosphorylation | Uniprot | |
Y253 | Phosphorylation | Uniprot | |
T409 | Phosphorylation | Uniprot | |
K438 | Ubiquitination | Uniprot | |
T441 | Phosphorylation | Uniprot | |
T442 | Phosphorylation | Uniprot | |
K465 | Ubiquitination | Uniprot | |
K473 | Ubiquitination | Uniprot | |
K488 | Ubiquitination | Uniprot | |
K502 | Ubiquitination | Uniprot | |
K567 | Ubiquitination | Uniprot | |
S573 | Phosphorylation | Uniprot | |
K582 | Ubiquitination | Uniprot | |
T585 | Phosphorylation | Uniprot | |
K589 | Ubiquitination | Uniprot | |
K603 | Ubiquitination | Uniprot | |
K611 | Ubiquitination | Uniprot | |
Y626 | Phosphorylation | Uniprot | |
K629 | Ubiquitination | Uniprot | |
K636 | Ubiquitination | Uniprot | |
S638 | Phosphorylation | Uniprot | |
K647 | Ubiquitination | Uniprot | |
R656 | Methylation | Uniprot | |
K685 | Ubiquitination | Uniprot | |
K694 | Ubiquitination | Uniprot | |
K716 | Ubiquitination | Uniprot | |
K729 | Ubiquitination | Uniprot | |
K746 | Ubiquitination | Uniprot | |
T761 | Phosphorylation | Uniprot | |
K764 | Acetylation | Uniprot | |
K775 | Ubiquitination | Uniprot | |
K783 | Ubiquitination | Uniprot | |
K800 | Ubiquitination | Uniprot | |
K820 | Acetylation | Uniprot | |
T828 | Phosphorylation | Uniprot | |
K857 | Ubiquitination | Uniprot | |
K872 | Ubiquitination | Uniprot | |
S904 | Phosphorylation | Uniprot |
Research Backgrounds
Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.
Membrane>Single-pass membrane protein. Cytoplasm.
Note: Slightly concentrates in the perinuclear region (PubMed:12118381).
Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).
Homodimer. Interacts with MYC. Interacts with PPP2R5C; this interaction stabilizes CIP2A. Interacts with PPP2R1A; this interaction stabilizes CIP2A.
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