Product: ABL1/2 Antibody
Catalog: AF6039
Description: Rabbit polyclonal antibody to ABL1/2
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Monkey
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 135kDa; 123kD,128kD(Calculated).
Uniprot: P00519 | P42684
RRID: AB_2834969

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Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Monkey
Prediction:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
ABL1/2 Antibody detects endogenous levels of total ABL1/2.
RRID:
AB_2834969
Cite Format: Affinity Biosciences Cat# AF6039, RRID:AB_2834969.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine protein kinase 1; Abl 1; ABL; ABL proto oncogene 1 non receptor tyrosine kinase; ABL1; ABL1_HUMAN; bcr/abl; bcr/c abl oncogene protein; c ABL; c abl oncogene 1 non receptor tyrosine kinase; c abl oncogene 1 receptor tyrosine kinase; c ABL1; JTK7; p150; Proto oncogene tyrosine protein kinase ABL1; Proto-oncogene c-Abl; Tyrosine-protein kinase ABL1; v abl Abelson murine leukemia viral oncogene homolog 1; v abl; Abelson murine leukemia viral oncogene homolog 2; Abelson related gene protein; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; ABL2; ABL2_HUMAN; ABLL; ARG; Tyrosine kinase ARG; Tyrosine protein kinase ABL2; Tyrosine-protein kinase ARG; v abl Abelson murine leukemia viral oncogene homolog 2;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
P00519 ABL1_HUMAN:

Widely expressed.

P42684 ABL2_HUMAN:

Widely expressed.

Description:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene.
Sequence:
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Zebrafish
100
Chicken
100
Rabbit
100
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P00519/P42684 As Substrate

Site PTM Type Enzyme
S43 Phosphorylation
S50 Phosphorylation
Y70 Phosphorylation P08631 (HCK) , P07948 (LYN) , P06241 (FYN) , P00519 (ABL1)
S75 Phosphorylation
Y93 Phosphorylation
S113 Phosphorylation
Y115 Phosphorylation P08631 (HCK) , P07948 (LYN) , P06241 (FYN)
T117 Phosphorylation
Y128 Phosphorylation P06241 (FYN) , P08631 (HCK) , P07948 (LYN)
Y139 Phosphorylation P07948 (LYN) , P08631 (HCK) , P06241 (FYN)
S142 Phosphorylation
Y167 Phosphorylation
Y172 Phosphorylation P07948 (LYN) , P08631 (HCK) , P06241 (FYN)
Y174 Phosphorylation
S180 Phosphorylation
Y185 Phosphorylation P08631 (HCK) , P07948 (LYN) , P06241 (FYN)
S187 Phosphorylation
Y215 Phosphorylation P08631 (HCK) , P07948 (LYN) , P06241 (FYN)
T224 Phosphorylation
Y226 Phosphorylation P06241 (FYN) , P08631 (HCK) , P12931 (SRC) , P07948 (LYN) , P00519 (ABL1)
S229 Phosphorylation
Y232 Phosphorylation
T243 Phosphorylation
Y253 Phosphorylation
Y257 Phosphorylation
Y264 Phosphorylation
S265 Phosphorylation
T267 Phosphorylation
K274 Acetylation
K285 Ubiquitination
T306 Phosphorylation
Y312 Phosphorylation
T315 Phosphorylation
Y320 Phosphorylation
T389 Phosphorylation
T392 Phosphorylation
Y393 Phosphorylation P08631 (HCK) , P07948 (LYN) , A0A173G4P4 (Abl fusion) , P06241 (FYN) , P12931 (SRC) , P00519 (ABL1)
T394 Phosphorylation
K400 Ubiquitination
Y413 Phosphorylation
S417 Phosphorylation
S446 Phosphorylation Q13315 (ATM)
S456 Phosphorylation
Y456 Phosphorylation
Y469 Phosphorylation
K512 Ubiquitination
T532 Phosphorylation
S535 Phosphorylation
S559 Phosphorylation
S569 Phosphorylation
T597 Phosphorylation
S601 Phosphorylation
T610 Phosphorylation
T613 Phosphorylation
S618 Phosphorylation Q13177 (PAK2)
S619 Phosphorylation Q13177 (PAK2)
S620 Phosphorylation
S642 Phosphorylation
T649 Phosphorylation
T653 Phosphorylation
S659 Phosphorylation
S676 Phosphorylation
S679 Phosphorylation
S683 Phosphorylation
K689 Methylation
S690 Phosphorylation
T692 Phosphorylation
S696 Phosphorylation
T700 Phosphorylation
S708 Phosphorylation
S709 Phosphorylation
S710 Phosphorylation
K711 Acetylation
S718 Phosphorylation
T735 Phosphorylation Q13043 (STK4) , P49759 (CLK1) , P41279 (MAP3K8) , Q9HAZ1 (CLK4) , Q13188 (STK3) , P33981 (TTK)
T751 Phosphorylation
K759 Acetylation
T781 Phosphorylation
S805 Phosphorylation
S808 Phosphorylation
S809 Phosphorylation
T814 Phosphorylation
T823 Phosphorylation
T844 Phosphorylation
T852 Phosphorylation
T854 Phosphorylation
S855 Phosphorylation
S859 Phosphorylation
S884 Phosphorylation
S915 Phosphorylation
S917 Phosphorylation
S919 Phosphorylation
T935 Phosphorylation
S936 Phosphorylation
S943 Phosphorylation
S949 Phosphorylation
T963 Phosphorylation
S977 Phosphorylation
Y1064 Phosphorylation
Y1070 Phosphorylation
S1106 Phosphorylation
T1111 Phosphorylation
Site PTM Type Enzyme
R23 Methylation
S31 Phosphorylation
T68 Phosphorylation
S71 Phosphorylation
S72 Phosphorylation
S96 Phosphorylation
S97 Phosphorylation
Y116 Phosphorylation
S121 Phosphorylation
Y139 Phosphorylation P09619 (PDGFRB)
S159 Phosphorylation
Y161 Phosphorylation P09619 (PDGFRB)
T163 Phosphorylation
Y174 Phosphorylation
S194 Phosphorylation
S200 Phosphorylation
S203 Phosphorylation
S208 Phosphorylation
Y213 Phosphorylation
Y218 Phosphorylation
Y231 Phosphorylation
Y261 Phosphorylation P00519 (ABL1) , P42684 (ABL2)
Y272 Phosphorylation P42684 (ABL2) , P09619 (PDGFRB)
S275 Phosphorylation
Y299 Phosphorylation
Y303 Phosphorylation
Y310 Phosphorylation
S311 Phosphorylation
T313 Phosphorylation
K320 Acetylation
K331 Ubiquitination
T435 Phosphorylation
T438 Phosphorylation
Y439 Phosphorylation P42684 (ABL2)
T440 Phosphorylation
K446 Ubiquitination
T452 Phosphorylation
Y459 Phosphorylation
Y515 Phosphorylation
Y568 Phosphorylation P42684 (ABL2)
S577 Phosphorylation
K578 Ubiquitination
T581 Phosphorylation
S602 Phosphorylation
S617 Phosphorylation
S618 Phosphorylation
S620 Phosphorylation
S631 Phosphorylation
S633 Phosphorylation
S634 Phosphorylation
S655 Phosphorylation
K659 Acetylation
T664 Phosphorylation
K667 Methylation
S671 Phosphorylation
Y683 Phosphorylation P42684 (ABL2)
Y718 Phosphorylation
T753 Phosphorylation
S781 Phosphorylation
S783 Phosphorylation
T784 Phosphorylation
K809 Ubiquitination
T815 Phosphorylation
S817 Phosphorylation
T818 Phosphorylation
S819 Phosphorylation
S820 Phosphorylation
T864 Phosphorylation
S866 Phosphorylation
S915 Phosphorylation
S936 Phosphorylation
T938 Phosphorylation
K957 Methylation
K957 Ubiquitination
K959 Methylation
S969 Phosphorylation
K981 Acetylation
T1050 Phosphorylation
S1051 Phosphorylation
S1054 Phosphorylation
K1057 Methylation
K1066 Methylation
S1107 Phosphorylation
T1112 Phosphorylation

Research Backgrounds

Function:

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717'. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity).

PTMs:

Acetylated at Lys-711 by EP300 which promotes the cytoplasmic translocation.

Phosphorylation at Tyr-70 by members of the SRC family of kinases disrupts SH3 domain-based autoinhibitory interactions and intermolecular associations, such as that with ABI1, and also enhances kinase activity. Phosphorylation at Tyr-226 and Tyr-393 correlate with increased activity. DNA damage-induced activation of ABL1 requires the function of ATM and Ser-446 phosphorylation (By similarity). Phosphorylation at Ser-569 has been attributed to a CDC2-associated kinase and is coupled to cell division (By similarity). Phosphorylation at Ser-618 and Ser-619 by PAK2 increases binding to CRK and reduces binding to ABI1. Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for cytoplasmic translocation. Phosphorylated by PRKDC (By similarity).

Polyubiquitinated. Polyubiquitination of ABL1 leads to degradation.

Subcellular Location:

Cytoplasm>Cytoskeleton. Nucleus. Mitochondrion.
Note: Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity).

Nucleus membrane>Lipid-anchor.
Note: The myristoylated c-ABL protein is reported to be nuclear.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed.

Subunit Structure:

Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16, ITGB1 and HCK (By similarity). Interacts with STX17; probably phosphorylates STX17. Interacts with INPPL1/SHIP2. Interacts with the 14-3-3 proteins, YWHAB, YWHAE, YWHAG, YWHAH, SFN AND YWHAZ; the interaction with 14-3-3 proteins requires phosphorylation on Thr-735 and, sequesters ABL1 into the cytoplasm. Interacts with ABI1, ABI2, BCR, CRK, FGR, FYN, HCK, LYN, PSMA7 RAD9A, RAD51, RAD52, TP73 and WASF3. A complex made of ABL1, CTTN and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Interacts (via SH3 domain) with CASP9; the interaction is direct and increases in the response of cells to genotoxic stress and ABL1/c-Abl activation. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases. Interacts with TBX21 (By similarity).

Family&Domains:

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.

Function:

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

PTMs:

Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity).

Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.

Subcellular Location:

Cytoplasm>Cytoskeleton.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed.

Subunit Structure:

Interacts with PSMA7. Interacts with CTTN. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.

Family&Domains:

Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are required to bundle actin filaments (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.

Research Fields

· Cellular Processes > Cell growth and death > Cell cycle.   (View pathway)

· Environmental Information Processing > Signal transduction > ErbB signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Pathogenic Escherichia coli infection.

· Human Diseases > Infectious diseases: Bacterial > Shigellosis.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia.   (View pathway)

· Human Diseases > Cardiovascular diseases > Viral myocarditis.

· Organismal Systems > Development > Axon guidance.   (View pathway)

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

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