SULT2B1 Antibody - #DF14095

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Product: SULT2B1 Antibody
Catalog: DF14095
Description: Rabbit polyclonal antibody to SULT2B1
Application: IHC
Reactivity: Human
Mol.Wt.: 41kD; 41kD(Calculated).
Uniprot: O00204

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
SULT2B1 Antibody detects endogenous levels of total SULT2B1.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Alcohol sulfotransferase; EC 2.8.2.2; HSST2; Hydroxysteroid sulfotransferase 2; ST2B1; ST2B1_HUMAN; Sulfotransferase 2B1; Sulfotransferase family cytosolic 2B member 1; SULT2B1; SULT2B1a; SULT2B1b;

Immunogens

Immunogen:

A synthesized peptide derived from Human SULT2B1.

Uniprot:

O00204(ST2B1_HUMAN) >>Visit HPA database.

Gene(ID):
SULT2B1(6820)
Expression:
O00204 ST2B1_HUMAN:

Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level) (PubMed:28575648). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung (PubMed:9799594).

Sequence:
MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETPHPRPS

Research Backgrounds

Function:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation.

Sulfonates pregnenolone but not cholesterol.

PTMs:

Phosphorylated.

Subcellular Location:

Cytoplasm>Cytosol. Microsome. Nucleus.
Note: Phosphorylation of Ser-348 is required for translocation to the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.

Family&Domains:

The C-terminus, which contains a proline/serine-rich region is involved in nuclear translocation and enzymatic thermostability.

Belongs to the sulfotransferase 1 family.

Research Fields

· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.

Restrictive clause

 

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