SRI Antibody - #DF14648

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Product: SRI Antibody
Catalog: DF14648
Description: Rabbit polyclonal antibody to SRI
Application: WB
Reactivity: Human, Mouse
Mol.Wt.: 22kD(Calculated).
Uniprot: P30626

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
SRI Antibody detects endogenous levels of SRI.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

22 kDa protein; Calcium binding protein amplified in mutlidrug resistant cells; CP 22; CP-22; CP22; SCN; Sorcin (class 4 gene); Sorcin; SORCN_HUMAN; SRI; V19;

Immunogens

Immunogen:

A synthesized peptide derived from human SRI.

Uniprot:

P30626(SORCN_HUMAN) >>Visit HPA database.

Gene(ID):
SRI(6717)
Expression:
P30626 SORCN_HUMAN:

Detected in cardiac myocytes.

Sequence:
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV

Research Backgrounds

Function:

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.

Subcellular Location:

Cytoplasm. Sarcoplasmic reticulum membrane>Peripheral membrane protein>Cytoplasmic side.
Note: Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Detected in cardiac myocytes.

Subunit Structure:

Homodimer. Interacts with GCA, RYR2 and ANXA7.

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