Product: PGRMC1 Mouse Monoclonal Antibody
Catalog: BF8084
Description: Mouse monoclonal antibody to PGRMC1
Application: WB
Reactivity: Human
Prediction: Pig, Bovine, Horse, Sheep, Rabbit
Mol.Wt.: 21kDa; 22kD(Calculated).
Uniprot: O00264

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 100ul $280 In stock
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Product Info

Source:
Mouse
Application:
WB 1:1000-1:10000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8084]
Specificity:
PGRMC1 Antibody detects endogenous levels of total PGRMC1.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HPR6.6; Membrane associated progesterone receptor component 1; Membrane-associated progesterone receptor component 1; mPR; PGRC1_HUMAN; PGRMC; Pgrmc1; Progesterone binding protein; Progesterone receptor membrane component 1;

Immunogens

Immunogen:

A synthesized peptide derived from human PGRMC1, corresponding to a region within C-terminal amino acids.

Uniprot:
Gene(ID):
Expression:
O00264 PGRC1_HUMAN:

Widely expressed, with highest expression in liver and kidney.

Description:
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney.
Sequence:
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND

PTMs - O00264 As Substrate

Site PTM Type Enzyme
R47 Methylation
S54 Phosphorylation
S57 Phosphorylation
T74 Phosphorylation
R79 Methylation
K96 Acetylation
K96 Ubiquitination
T101 Phosphorylation
K102 Ubiquitination
K105 Ubiquitination
Y107 Phosphorylation
Y113 Phosphorylation
R119 Methylation
K132 Ubiquitination
K136 Ubiquitination
Y139 Phosphorylation
S143 Phosphorylation
T146 Phosphorylation
T152 Phosphorylation
S154 Phosphorylation
K163 Ubiquitination
K169 Ubiquitination
K172 Ubiquitination
T178 Phosphorylation
Y180 Phosphorylation
S181 Phosphorylation
K187 Ubiquitination
S190 Phosphorylation

Research Backgrounds

Function:

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs).

Subcellular Location:

Microsome membrane>Single-pass membrane protein. Smooth endoplasmic reticulum membrane>Single-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed, with highest expression in liver and kidney.

Subunit Structure:

Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.

Family&Domains:

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.

Belongs to the cytochrome b5 family. MAPR subfamily.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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