FRK Antibody - #DF3179
| Product: | FRK Antibody |
| Catalog: | DF3179 |
| Description: | Rabbit polyclonal antibody to FRK |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Sheep, Dog |
| Mol.Wt.: | 55 KD; 58kD(Calculated). |
| Uniprot: | P42685 |
| RRID: | AB_2835402 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3179, RRID:AB_2835402.
Fold/Unfold
Beta cell Src homology tyrosine kinase; BSK; BSK/IYK; C85044; Frk; Frk fyn related kinase; FRK_HUMAN; FYN related kinase; FYN-related kinase; GASK; Gastrointestinal associated kinase; Gastrointestinal associated tyrosine kinase; GTK; GTK, mouse, homolog of; Intestine tyrosine kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; PTK5; PTK5 protein tyrosine kinase 5; RAK; Tyrosine protein kinase FRK; Tyrosine-protein kinase FRK;
Immunogens
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
- P42685 FRK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P42685 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S37 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| Y46 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| Y132 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| T178 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| Y193 | Phosphorylation | Uniprot | |
| Y221 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| Y303 | Phosphorylation | Uniprot | |
| Y317 | Phosphorylation | Uniprot | |
| Y368 | Phosphorylation | Uniprot | |
| Y387 | Phosphorylation | P42685 (FRK) | Uniprot |
| S389 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| K409 | Acetylation | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| Y497 | Phosphorylation | P41240 (CSK) | Uniprot |
| S498 | Phosphorylation | Uniprot |
PTMs - P42685 As Enzyme
Research Backgrounds
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Cytoplasm. Nucleus.
Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
Interacts (via the SH3-domain) with PTEN. Interacts with RB1.
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.