SFRS17A Antibody - #DF3235

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Product: SFRS17A Antibody
Catalog: DF3235
Description: Rabbit polyclonal antibody to SFRS17A
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Horse, Dog, Chicken
Mol.Wt.: 81 KD; 81kD(Calculated).
Uniprot: Q02040
RRID: AB_2835615

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Horse(86%), Dog(86%), Chicken(83%)
Clonality:
Polyclonal
Specificity:
SFRS17A Antibody detects endogenous levels of total SFRS17A.
RRID:
AB_2835615
Cite Format: Affinity Biosciences Cat# DF3235, RRID:AB_2835615.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

721P; A-kinase anchor protein 17A; AK17A_HUMAN; AKAP-17A; AKAP17A; arginine/serine-rich 17A; B lymphocyte antigen; B lymphocyte surface antigen; B-lymphocyte antigen; CCDC133; PRKA17A; Protein kinase A-anchoring protein 17A; Protein XE7; Pseudoautosomal gene XE7; SFRS 17A; Splicing factor; Splicing factor arginine/serine rich 17A; XE 7; XE7;

Immunogens

Immunogen:
Uniprot:

Q02040(AK17A_HUMAN) >>Visit HPA database.

Gene(ID):
AKAP17A(8227)
Expression:
Q02040 AK17A_HUMAN:

Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells.

Sequence:
MAAATIVHDTSEAVELCPAYGLYLKPITKMTISVALPQLKQPGKSISNWEVMERLKGMVQNHQFSTLRISKSTMDFIRFEGEVENKSLVKSFLACLDGKTIKLSGFSDILKVRAAEFKIDFPTRHDWDSFFRDAKDMNETLPGERPDTIHLEGLPCKWFALKESGSEKPSEDVLVKVFEKFGEIRNVDIPMLDPYREEMTGRNFHTFSFGGHLNFEAYVQYREYMGFIQAMSALRGMKLMYKGEDGKAVACNIKVSFDSTKHLSDASIKKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRLQEAELRRVEEEKERALGLQRKERELRERLLSILLSKKPDDSHTHDELGVAHADLLQPVLDILQTVSSGCVSATTLHPLGGQPPAGAPKESPAHPEADGAPKSVNGSVAEEAPCKEVQSSCRVVPEDGSPEKRCPGGVLSCIPDNNQQPKGIPACEQNVSRKDTRSEQDKCNREPSKGRGRATGDGLADRHKRERSRARRASSREDGRPRKERRPHKKHAYKDDSPRRRSTSPDHTRSRRSHSKDRHRRERSRERRGSASRKHSRHRRRSERSRSRSPSRHRSTWNR

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
86
Dog
86
Chicken
83
Pig
0
Bovine
0
Sheep
0
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q02040 As Substrate

Site PTM Type Enzyme
K44 Ubiquitination
K86 Ubiquitination
S87 Phosphorylation
S91 Phosphorylation
K99 Ubiquitination
K118 Sumoylation
K162 Ubiquitination
K180 Ubiquitination
K317 Acetylation
K324 Acetylation
K339 Acetylation
K350 Ubiquitination
S440 Phosphorylation
S444 Phosphorylation
S499 Phosphorylation
S511 Phosphorylation
S515 Phosphorylation
S537 Phosphorylation
S548 Phosphorylation
S584 Phosphorylation
R598 Methylation
S611 Phosphorylation
S633 Phosphorylation
S638 Phosphorylation
T639 Phosphorylation
S640 Phosphorylation
S685 Phosphorylation
S687 Phosphorylation

Research Backgrounds

Function:

Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.

Subcellular Location:

Nucleus speckle.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells.

Subunit Structure:

Monomer. Component of the spliceosome. Interacts with ZRANB2 and SFRS1/ASF through its Arg/Ser-rich domain. Interacts with RI and RII subunits of PKA.

Family&Domains:

RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Restrictive clause

 

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For Research Use Only.
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