Calcipressin 1 Antibody - #DF3861

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Product: Calcipressin 1 Antibody
Catalog: DF3861
Description: Rabbit polyclonal antibody to Calcipressin 1
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 22 KD; 28kD(Calculated).
Uniprot: P53805
RRID: AB_2836218

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
Calcipressin 1 Antibody detects endogenous levels of total Calcipressin 1.
RRID:
AB_2836218
Cite Format: Affinity Biosciences Cat# DF3861, RRID:AB_2836218.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Adapt 78; Adapt78; Calcipressin 1; Calcipressin-1; Calcium and oxidant inducible mRNA; CSP 1; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC 1; DSC1; DSCR 1; DSCR1; MCIP 1; MCIP1; Modulatory calcineurin interacting protein 1; Myocyte enriched calcineurin interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; Near DSCR proline rich protein; RCAN1; RCAN1_HUMAN; RCN 1; RCN1; Regulator of calcineurin 1;

Immunogens

Immunogen:
Uniprot:

P53805(RCAN1_HUMAN) >>Visit HPA database.

Gene(ID):
RCAN1(1827)
Expression:
P53805 RCAN1_HUMAN:

Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

Sequence:
MEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P53805 As Substrate

Site PTM Type Enzyme
K86 Ubiquitination
Y94 Phosphorylation
K128 Ubiquitination
T129 Phosphorylation
K134 Ubiquitination
S163 Phosphorylation Q99759 (MAP3K3) , P49841 (GSK3B)
S167 Phosphorylation Q99759 (MAP3K3) , Q13627 (DYRK1A) , P27361 (MAPK3) , P28482 (MAPK1)
T179 Phosphorylation
Y188 Phosphorylation
K192 Ubiquitination
T208 Phosphorylation
S218 Phosphorylation
T241 Phosphorylation
T247 Phosphorylation Q13627 (DYRK1A)

Research Backgrounds

Function:

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).

PTMs:

Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.

Tissue Specificity:

Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

Subunit Structure:

Interacts with RAF1. Interacts with PPP3CA and PPP3R1.

Family&Domains:

Belongs to the RCAN family.

Research Fields

· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

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