CLCNKA Antibody - #DF3933
| Product: | CLCNKA Antibody |
| Catalog: | DF3933 |
| Description: | Rabbit polyclonal antibody to CLCNKA |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Dog |
| Mol.Wt.: | 75 KD; 75kD(Calculated). |
| Uniprot: | P51800 |
| RRID: | AB_2836286 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3933, RRID:AB_2836286.
Fold/Unfold
C75963; Chloride channel Ka; Chloride channel kidney A; Chloride channel protein ClC Ka; Chloride channel protein ClC-Ka; ClC K1; ClC-K1; CLCK1; hClC Ka; MGC61490; MGC93313; RP23-308N2.5;
Immunogens
Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.
- P51800 CLCKA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P51800 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S655 | Phosphorylation | Uniprot | |
| S660 | Phosphorylation | Uniprot |
Research Backgrounds
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
Membrane>Multi-pass membrane protein.
Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.
Homodimer. Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle (By similarity).
Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily.
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