CLIC6 Antibody - #DF3934
| Product: | CLIC6 Antibody |
| Catalog: | DF3934 |
| Description: | Rabbit polyclonal antibody to CLIC6 |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Rabbit |
| Mol.Wt.: | 73 KD; 73kD(Calculated). |
| Uniprot: | Q96NY7 |
| RRID: | AB_2836287 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3934, RRID:AB_2836287.
Fold/Unfold
Chloride channel form A; Chloride intracellular channel 6; Chloride intracellular channel protein 6; CLIC1L; Clic6; CLIC6_HUMAN; Parchorin;
Immunogens
- Q96NY7 CLIC6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLAPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKALRKLDNYLNSPLPDEIDAYSTEDVTVSGRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVAKRMK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96NY7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S44 | Phosphorylation | Uniprot | |
| S112 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| S239 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| S414 | Phosphorylation | Uniprot | |
| S426 | Phosphorylation | Uniprot | |
| Y479 | Phosphorylation | Uniprot | |
| T624 | Phosphorylation | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| K629 | Ubiquitination | Uniprot |
Research Backgrounds
May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).
Phosphorylated.
Cytoplasm. Cell membrane>Single-pass membrane protein.
Note: Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity).
Expressed in brain, placenta, pancreas and liver.
Interacts with dopamine receptors DRD2, DRD3 and DRD4.
Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
Belongs to the chloride channel CLIC family.
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