CSPG5 Antibody - #DF3938
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| Product: | CSPG5 Antibody |
| Catalog: | DF3938 |
| Description: | Rabbit polyclonal antibody to CSPG5 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Rabbit, Dog |
| Mol.Wt.: | 60 KD; 60kD(Calculated). |
| Uniprot: | O95196 |
| RRID: | AB_2836291 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3938, RRID:AB_2836291.
Fold/Unfold
Acidic leucine rich EGF like domain containing brain protein; Acidic leucine-rich EGF-like domain-containing brain protein; Caleb; Chondroitin sulfate proteoglycan 5 (neuroglycan C); Chondroitin sulfate proteoglycan 5; CSPG5; CSPG5_HUMAN; MGC44034; Neuroglycan C; Ngc; OTTHUMP00000164796; OTTHUMP00000164797; OTTHUMP00000210429;
Immunogens
- O95196 CSPG5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGRAGGGGPGRGPPPLLLFLGAALVLASGAVPAREAGSAVEAEELVKGSPAWEPPANDTREEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLEADSPGLGGVTAEAGSGDAQALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDKLSPASELPKESPLEVWLNLGGSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLDEEEEEEEDDKDAVGGGDLEDENELLVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPGSSIALRPRPGEPGRDLASSENGTECRSGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCNTPRTSSPHARALAHYDNVICQDDPSAPHKIQEVLKSCLKEEESFNIQNSMSPKLEGGKGDQADLDVNCLQNNLT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95196 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S162 | O-Glycosylation | Uniprot | |
| S165 | O-Glycosylation | Uniprot | |
| T328 | O-Glycosylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| Y507 | Phosphorylation | Uniprot | |
| K531 | Ubiquitination | Uniprot |
Research Backgrounds
May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
N-glycosylated.
O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation (By similarity).
Phosphorylated; in intracellular and extracellular parts.
Cell membrane>Single-pass type I membrane protein. Cell junction>Synapse>Synaptic cell membrane>Single-pass type I membrane protein. Endoplasmic reticulum membrane>Single-pass type I membrane protein. Golgi apparatus membrane>Single-pass type I membrane protein. Cell surface.
Note: In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts.
Restricted to brain (at protein level).
Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC. Interacts with MDK; this interaction is independent of the presence of chondroitin sulfate chains and promotes elongation of oligodendroglial precursor-like cells (By similarity).
References
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