SLC25A21 Antibody - #DF4172

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Product: SLC25A21 Antibody
Catalog: DF4172
Description: Rabbit polyclonal antibody to SLC25A21
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit
Mol.Wt.: 36 KD; 33kD(Calculated).
Uniprot: Q9BQT8
RRID: AB_2836537

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(82%), Bovine(83%), Horse(82%), Sheep(82%), Rabbit(82%)
Clonality:
Polyclonal
Specificity:
SLC25A21 Antibody detects endogenous levels of total SLC25A21.
RRID:
AB_2836537
Cite Format: Affinity Biosciences Cat# DF4172, RRID:AB_2836537.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Mitochondrial 2-oxodicarboxylate carrier; ODC; ODC_HUMAN; ODC1; oxodicarboxylate carrier; Slc25a21; Solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21; Solute carrier family 25 member 21;

Immunogens

Immunogen:
Uniprot:

Q9BQT8(ODC_HUMAN) >>Visit HPA database.

Gene(ID):
SLC25A21(89874)
Expression:
Q9BQT8 ODC_HUMAN:

Ubiquitous.

Sequence:
MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Bovine
83
Pig
82
Horse
82
Sheep
82
Rabbit
82
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9BQT8 As Substrate

Site PTM Type Enzyme
Y153 Phosphorylation

Research Backgrounds

Function:

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

Subcellular Location:

Mitochondrion inner membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous.

Family&Domains:

Belongs to the mitochondrial carrier (TC 2.A.29) family.

References

1). SLC25A21 Suppresses Cell Growth in Bladder Cancer via an Oxidative Stress-Mediated Mechanism. Frontiers in Oncology (PubMed: 34568013) [IF=4.7]

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