KCNK4 Antibody - #DF4309
| Product: | KCNK4 Antibody |
| Catalog: | DF4309 |
| Description: | Rabbit polyclonal antibody to KCNK4 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Rabbit, Dog |
| Mol.Wt.: | 45 KD; 43kD(Calculated). |
| Uniprot: | Q9NYG8 |
| RRID: | AB_2836677 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4309, RRID:AB_2836677.
Fold/Unfold
K2p4.1; K2P4.1 potassium channel; KCNK 4; MGC144821; Potassium channel subfamily K member 4; Potassium inwardly rectifying channel subfamily K member 4; TRAAK; TRAAK1; TRAAKt; TWIK related arachidonic acid stimulated potassium channel protein; Two pore K(+) channel KT4.1; Two pore K+ channel KT4.1; Two pore potassium channel KT4.1;
Immunogens
- Q9NYG8 KCNK4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NYG8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y218 | Phosphorylation | Uniprot |
Research Backgrounds
Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).
N-glycosylated.
Cell membrane>Multi-pass membrane protein.
Homodimer; disulfide-linked.
Channel opening is brought about by a conformation change that involves buckling of the second transmembrane helix and affects the position and orientation of the fourth transmembrane helix.
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
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