ZP4 Antibody - #DF4642
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4642, RRID:AB_2836933.
Fold/Unfold
Processed zona pellucida sperm-binding protein 4; ZBP; Zona pellucida B protein; Zona pellucida glycoprotein 4; Zona pellucida protein B; Zona pellucida sperm binding protein 4; Zp-4; ZP1; ZP4; ZP4_HUMAN; ZPB;
Immunogens
- Q12836 ZP4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWLLRCVLLCVSLSLAVSGQHKPEAPDYSSVLHCGPWSFQFAVNLNQEATSPPVLIAWDNQGLLHELQNDSDCGTWIRKGPGSSVVLEATYSSCYVTEWDSHYIMPVGVEGAGAAEHKVVTERKLLKCPMDLLARDAPDTDWCDSIPARDRLPCAPSPISRGDCEGLGCCYSSEEVNSCYYGNTVTLHCTREGHFSIAVSRNVTSPPLLLDSVRLALRNDSACNPVMATQAFVLFQFPFTSCGTTRQITGDRAVYENELVATRDVKNGSRGSVTRDSIFRLHVSCSYSVSSNSLPINVQVFTLPPPFPETQPGPLTLELQIAKDKNYGSYYGVGDYPVVKLLRDPIYVEVSILHRTDPYLGLLLQQCWATPSTDPLSQPQWPILVKGCPYIGDNYQTQLIPVQKALDLPFPSHHQRFSIFTFSFVNPTVEKQALRGPVHLHCSVSVCQPAETPSCVVTCPDLSRRRNFDNSSQNTTASVSSKGPMILLQATKDPPEKLRVPVDSKVLWVAGLSGTLILGALLVSYLAVKKQKSCPDQMCQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q12836 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y327 | Phosphorylation | Uniprot | |
| Y330 | Phosphorylation | Uniprot | |
| Y331 | Phosphorylation | Uniprot | |
| Y347 | Phosphorylation | Uniprot | |
| Y390 | Phosphorylation | Uniprot | |
| Y395 | Phosphorylation | Uniprot | |
| T428 | Phosphorylation | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| T475 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| S513 | Phosphorylation | Uniprot | |
| Y525 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
Secreted>Extracellular space>Extracellular matrix.
Note: Located in oocyte zona pellucida.
Cell membrane>Single-pass type I membrane protein.
Expressed in oocytes.
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Belongs to the ZP domain family. ZPB subfamily.
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