CFHR1 Antibody - #DF7070

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Product: CFHR1 Antibody
Catalog: DF7070
Description: Rabbit polyclonal antibody to CFHR1
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 38kDa; 38kD(Calculated).
Uniprot: Q03591
RRID: AB_2839026

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
CFHR1 Antibody detects endogenous levels of total CFHR1.
RRID:
AB_2839026
Cite Format: Affinity Biosciences Cat# DF7070, RRID:AB_2839026.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CFHL; CFHL1; CFHL1P; CFHR1; CFHR1P; Complement factor H related 1; Complement factor H related 1 pseudogene; Complement factor H related protein 1 precursor; Complement factor H-related protein 1; FHR 1; FHR-1; FHR1; FHR1_HUMAN; H factor (complement) like 1; H factor (complement) like 2; H factor like protein 1; H factor-like protein 1; H-factor-like 1; H36 1; H36 2; H36; HFL1; HFL2; MGC104329;

Immunogens

Immunogen:
Uniprot:

Q03591(FHR1_HUMAN) >>Visit HPA database.

Gene(ID):
CFHR1(3078)
Expression:
Q03591 FHR1_HUMAN:

Expressed by the liver and secreted in plasma.

Description:
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
Sequence:
MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR

PTMs - Q03591 As Substrate

Site PTM Type Enzyme
N126 N-Glycosylation
N194 N-Glycosylation
S269 Phosphorylation

Research Backgrounds

Function:

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.

PTMs:

N-glycosylated. Two forms are observed; one with a single side chain and the other with two.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed by the liver and secreted in plasma.

Subunit Structure:

Head-to-tail homodimer and heterodimer with CFHR2 or CFHR5.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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