RAMP2 Antibody - #DF7173

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Product: RAMP2 Antibody
Catalog: DF7173
Description: Rabbit polyclonal antibody to RAMP2
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 20kD; 20kD(Calculated).
Uniprot: O60895
RRID: AB_2839125

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
RAMP2 Antibody detects endogenous levels of total RAMP2.
RRID:
AB_2839125
Cite Format: Affinity Biosciences Cat# DF7173, RRID:AB_2839125.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Calcitonin receptor like receptor activity modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity modifying protein 2; CRLR activity-modifying protein 2; OTTMUSP00000002615; OTTMUSP00000037624; RAMP2; RAMP2_HUMAN; Receptor (calcitonin) activity modifying protein 2; Receptor activity modifying protein 2; Receptor activity modifying protein 2 isoform; Receptor activity-modifying protein 2; RP23-281C18.6;

Immunogens

Immunogen:
Uniprot:

O60895(RAMP2_HUMAN) >>Visit HPA database.

Gene(ID):
RAMP2(10266)
Expression:
O60895 RAMP2_HUMAN:

Strongly expressed in lung, breast, immune system and fetal tissues.

Sequence:
MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQPLPTTGTPGSEGGTVKNYETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFAELFDLGFPNPLAERIIFETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA

Research Backgrounds

Function:

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Subcellular Location:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Strongly expressed in lung, breast, immune system and fetal tissues.

Subunit Structure:

Heterodimer of CALCRL and RAMP2.

Family&Domains:

Belongs to the RAMP family.

Research Fields

· Organismal Systems > Circulatory system > Vascular smooth muscle contraction.   (View pathway)

References

1). Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes. ACTA DIABETOLOGICA (PubMed: 34978596) [IF=3.8]

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For Research Use Only.
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