APR3 Antibody - #DF2273

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Product: APR3 Antibody
Catalog: DF2273
Description: Rabbit polyclonal antibody to APR3
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 22 kDa; 25kD(Calculated).
Uniprot: Q6UW56
RRID: AB_2839502

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
APR3 Antibody detects endogenous levels of total APR3.
RRID:
AB_2839502
Cite Format: Affinity Biosciences Cat# DF2273, RRID:AB_2839502.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Apoptosis related protein 3; Apoptosis related protein APR 3; APR 3; APR3; Chromosome 2 open reading frame 28; HSPC013; p18; PRO240;

Immunogens

Immunogen:
Uniprot:

Q6UW56(ARAID_HUMAN) >>Visit HPA database.

Gene(ID):
ATRAID(51374)
Expression:
Q6UW56 ARAID_HUMAN:

Weakly expressed in hematopoietic cell lines.

Sequence:
MAPHDPGSLTTLVPWAAALLLALGVERALALPEICTQCPGSVQNLSKVAFYCKTTRELMLHARCCLNQKGTILGLDLQNCSLEDPGPNFHQAHTTVIIDLQANPLKGDLANTFRGFTQLQTLILPQHVNCPGGINAWNTITSYIDNQICQGQKNLCNNTGDPEMCPENGSCVPDGPGLLQCVCADGFHGYKCMRQGSFSLLMFFGILGATTLSVSILLWATQRRKAKTS

PTMs - Q6UW56 As Substrate

Site PTM Type Enzyme
K53 Ubiquitination

Research Backgrounds

Function:

Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.

Subcellular Location:

Nucleus envelope. Cell membrane>Single-pass membrane protein.
Note: Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Weakly expressed in hematopoietic cell lines.

Subunit Structure:

Interacts with NELL1; the interaction promotes osteoblastic differentiation and mineralization.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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