Product: SNRK Antibody
Catalog: DF2681
Description: Rabbit polyclonal antibody to SNRK
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 84 kDa; 84kD(Calculated).
Uniprot: Q9NRH2
RRID: AB_2839887

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
SNRK Antibody detects endogenous levels of total SNRK.
RRID:
AB_2839887
Cite Format: Affinity Biosciences Cat# DF2681, RRID:AB_2839887.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DKFZp779A1866; FLJ20224; HSNFRK; KIAA0096; SNF related kinase; SNF related serine/threonine protein kinase; SNF-related serine/threonine-protein kinase; SNF1 related kinase; SNF1-related kinase; SNFRK; Snrk; SNRK_HUMAN;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q9NRH2 SNRK_HUMAN:

Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.

Description:
May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.;
Sequence:
MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHGSTKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELERIKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9NRH2 As Substrate

Site PTM Type Enzyme
K11 Acetylation
K11 Ubiquitination
K20 Ubiquitination
T21 Phosphorylation
K41 Ubiquitination
K45 Ubiquitination
K68 Acetylation
K141 Ubiquitination
K150 Ubiquitination
T157 Phosphorylation
S162 Phosphorylation
K164 Ubiquitination
T172 Phosphorylation
T173 Phosphorylation Q15831 (STK11)
S174 Phosphorylation
S259 Phosphorylation
S275 Phosphorylation
K279 Ubiquitination
S351 Phosphorylation
S362 Phosphorylation
T380 Phosphorylation
S390 Phosphorylation
S460 Phosphorylation
T463 Phosphorylation
S482 Phosphorylation
S495 Phosphorylation
S518 Phosphorylation
T521 Phosphorylation
S531 Phosphorylation
R534 Methylation
S536 Phosphorylation
S537 Phosphorylation
T543 Phosphorylation
S550 Phosphorylation
Y562 Phosphorylation
S563 Phosphorylation
S569 Phosphorylation
S570 Phosphorylation
S607 Phosphorylation
T617 Phosphorylation
T619 Phosphorylation
T623 Phosphorylation
S639 Phosphorylation
K727 Ubiquitination
K738 Ubiquitination
K749 Ubiquitination

Research Backgrounds

Function:

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.

PTMs:

Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.

Family&Domains:

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Restrictive clause

 

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