DOK6 Antibody - #AF0767
| Product: | DOK6 Antibody |
| Catalog: | AF0767 |
| Description: | Rabbit polyclonal antibody to DOK6 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 43kDa; 38kD(Calculated). |
| Uniprot: | Q6PKX4 |
| RRID: | AB_2834290 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0767, RRID:AB_2834290.
Fold/Unfold
Docking protein 5; Docking protein 5 like; Docking protein 6; DOK 6; DOK5; DOK5L; DOK6; Downstream of tyrosine kinase 6; HsT3226; MGC20785; Protein dok 5;
Immunogens
Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
- Q6PKX4 DOK6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQQPLSRSSSYGFSYSSSLIQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6PKX4 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K58 | Methylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| Y220 | Phosphorylation | Uniprot | |
| T249 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot |
Research Backgrounds
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.
On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.
Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
Interacts via its PTB domain with phosphorylated RET.
PTB domain mediates receptor interaction.
Belongs to the DOK family. Type B subfamily.
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