MAGEA2 Antibody - #DF10029
| Product: | MAGEA2 Antibody |
| Catalog: | DF10029 |
| Description: | Rabbit polyclonal antibody to MAGEA2 |
| Application: | WB |
| Reactivity: | Human |
| Mol.Wt.: | 35 kDa; 35kD(Calculated). |
| Uniprot: | P43356 |
| RRID: | AB_2840609 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF10029, RRID:AB_2840609.
Fold/Unfold
Cancer/testis antigen 1.2; Cancer/testis antigen family 1, member 2; CT1.2; MAGE 2; MAGE 2 antigen; MAGE2; MAGEA 2; MAGEA2; MAGEA2A; MAGEA2B; Melanoma antigen 2; Melanoma antigen family A, 2; Melanoma antigen family A, 2B; Melanoma antigen, family A, 2, copy b; Melanoma associated antigen 2;
Immunogens
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
- P43356 MAGA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSSTLVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSDEGSSNQEEEGPRMFPDLESEFQAAISRKMVELVHFLLLKYRAREPVTKAEMLESVLRNCQDFFPVIFSKASEYLQLVFGIEVVEVVPISHLYILVTCLGLSYDGLLGDNQVMPKTGLLIIVLAIIAIEGDCAPEEKIWEELSMLEVFEGREDSVFAHPRKLLMQDLVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHTLKIGGEPHISYPPLHERALREGEE
PTMs - P43356 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Sumoylation | Uniprot | |
| T131 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K244 | Ubiquitination | Uniprot |
Research Backgrounds
Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.
Nucleus. Nucleus>PML body.
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
Interacts with TRIM28 and UBE2H. Interacts with HDAC3. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5).
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