MAGEA3 Antibody - #DF10030
| Product: | MAGEA3 Antibody |
| Catalog: | DF10030 |
| Description: | Rabbit polyclonal antibody to MAGEA3 |
| Application: | WB |
| Reactivity: | Human, Monkey |
| Mol.Wt.: | 35 kDa; 35kD(Calculated). |
| Uniprot: | P43357 |
| RRID: | AB_2840610 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF10030, RRID:AB_2840610.
Fold/Unfold
Antigen MZ2 D; Antigen MZ2-D; Cancer/testis antigen 1.3; Cancer/testis antigen family 1 member 3; CT1.3; HIP8; HYPD; MAGA3_HUMAN; MAGE 3 antigen; MAGE-3 antigen; MAGE3; MAGEA3; MAGEA6; Melanoma antigen family A 3; Melanoma associated antigen 3; Melanoma-associated antigen 3; MGC1461;
Immunogens
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas.
- P43357 MAGA3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE
PTMs - P43357 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Sumoylation | Uniprot | |
| K11 | Ubiquitination | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| Y124 | Phosphorylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| T247 | Phosphorylation | Uniprot | |
| Y258 | Phosphorylation | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| K292 | Ubiquitination | Uniprot |
Research Backgrounds
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas.
Interacts with TRIM28.
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