MAGEA6 Antibody - #DF10031
| Product: | MAGEA6 Antibody |
| Catalog: | DF10031 |
| Description: | Rabbit polyclonal antibody to MAGEA6 |
| Application: | WB |
| Reactivity: | Human, Monkey |
| Mol.Wt.: | 35 kDa; 35kD(Calculated). |
| Uniprot: | P43360 |
| RRID: | AB_2840611 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF10031, RRID:AB_2840611.
Fold/Unfold
Cancer/testis antigen 1.6; Cancer/testis antigen family 1, member 6; CT1.6; MAGA6_HUMAN; MAGE 3b; MAGE 6 antigen; MAGE-6 antigen; MAGE3B; MAGE3B antigen; MAGE6; MAGEA6; Melanoma antigen family A 6; Melanoma associated antigen 6; Melanoma-associated antigen 6;
Immunogens
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
- P43360 MAGA6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQLVFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPEEKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEE
PTMs - P43360 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Sumoylation | Uniprot | |
| K11 | Ubiquitination | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| T247 | Phosphorylation | Uniprot | |
| Y249 | Phosphorylation | Uniprot | |
| Y255 | Phosphorylation | Uniprot | |
| Y258 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot |
Research Backgrounds
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
Interacts with TRIM28.
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