CIC Antibody - #DF10074

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Product: CIC Antibody
Catalog: DF10074
Description: Rabbit polyclonal antibody to CIC
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 164 kDa; 164kD(Calculated).
Uniprot: Q96RK0
RRID: AB_2840654

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
CIC Antibody detects endogenous levels of total CIC.
RRID:
AB_2840654
Cite Format: Affinity Biosciences Cat# DF10074, RRID:AB_2840654.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Capicua homolog (Drosophila); Cic; CIC_HUMAN; KIAA0306; Protein capicua homolog;

Immunogens

Immunogen:
Uniprot:

Q96RK0(CIC_HUMAN) >>Visit HPA database.

Gene(ID):
CIC(23152)
Expression:
Q96RK0 CIC_HUMAN:

Expressed in fetal brain.

Sequence:
MYSAHRPLMPASSAASRGLGMFVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPTSLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSDTKAPGSSSCGAERLHTVGGPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSTQYGAPGPFAAPGEGGALAATGRPPLLPTRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDGFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPGPSVIAAPPSGGGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDSVDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPPLPPPPESGPGQPGWEGAPQPSPPPPGPSTAATGR

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96RK0 As Substrate

Site PTM Type Enzyme
R30 Methylation
S77 Phosphorylation
S105 Phosphorylation
S132 Phosphorylation
S142 Phosphorylation
T144 Phosphorylation
S146 Phosphorylation
T171 Phosphorylation
S173 Phosphorylation Q15418 (RPS6KA1) , P51812 (RPS6KA3)
S175 Phosphorylation
S191 Phosphorylation
S211 Phosphorylation
S231 Phosphorylation
S277 Phosphorylation
S278 Phosphorylation
S279 Phosphorylation
S285 Phosphorylation
T295 Phosphorylation
S299 Phosphorylation
S301 Phosphorylation
T303 Phosphorylation
T305 Phosphorylation
S333 Phosphorylation
S335 Phosphorylation
T343 Phosphorylation
S349 Phosphorylation
S356 Phosphorylation
S358 Phosphorylation
S362 Phosphorylation
S370 Phosphorylation
S431 Phosphorylation
T435 Phosphorylation
S436 Phosphorylation
T472 Phosphorylation
S474 Phosphorylation
S496 Phosphorylation
T556 Phosphorylation
R572 Methylation
T583 Phosphorylation P24941 (CDK2)
S585 Phosphorylation P24941 (CDK2)
K586 Methylation
R599 Methylation
S605 Phosphorylation
K689 Acetylation
S700 Phosphorylation
S721 Phosphorylation
S726 Phosphorylation
S730 Phosphorylation
S734 Phosphorylation
S739 Phosphorylation
R863 Methylation
S894 Phosphorylation
S902 Phosphorylation
S904 Phosphorylation
S914 Phosphorylation
R934 Methylation
S946 Phosphorylation
S982 Phosphorylation
S1150 Phosphorylation
S1173 Phosphorylation
T1228 Phosphorylation
S1245 Phosphorylation
S1246 Phosphorylation
T1291 Phosphorylation
S1294 Phosphorylation
S1306 Phosphorylation
S1307 Phosphorylation
T1318 Phosphorylation
S1344 Phosphorylation
S1351 Phosphorylation
S1373 Phosphorylation
T1375 Phosphorylation
S1378 Phosphorylation
T1381 Phosphorylation
S1382 Phosphorylation
S1389 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3)
S1397 Phosphorylation
T1398 Phosphorylation
S1402 Phosphorylation
T1408 Phosphorylation
S1409 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1)
S1418 Phosphorylation
S1419 Phosphorylation
S1422 Phosphorylation
T1426 Phosphorylation
S1429 Phosphorylation
S1462 Phosphorylation
S1595 Phosphorylation

Research Backgrounds

Function:

Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in fetal brain.

Subunit Structure:

Interacts with ATXN1 and ATXN1L. Found in a complex with ATXN1 and ATXN1L.

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