STRN Antibody - #DF10123

(3)  
Product: STRN Antibody
Catalog: DF10123
Description: Rabbit polyclonal antibody to STRN
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 86 kDa; 86kD(Calculated).
Uniprot: O43815
RRID: AB_2840703

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Zebrafish(92%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(92%), Dog(100%), Chicken(92%), Xenopus(83%)
Clonality:
Polyclonal
Specificity:
STRN Antibody detects endogenous levels of total STRN.
RRID:
AB_2840703
Cite Format: Affinity Biosciences Cat# DF10123, RRID:AB_2840703.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

MGC125642; SG2NA; Striatin; Striatin Calmodulin binding protein; STRN; STRN_HUMAN;

Immunogens

Immunogen:
Uniprot:

O43815(STRN_HUMAN) >>Visit HPA database.

Gene(ID):
STRN(6801)
Expression:
O43815 STRN_HUMAN:

Preferentially expressed in brain.

Sequence:
MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
92
Chicken
92
Rabbit
92
Xenopus
83
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O43815 As Substrate

Site PTM Type Enzyme
K110 Ubiquitination
Y135 Phosphorylation
S137 Phosphorylation
T143 Phosphorylation
T172 Phosphorylation
T174 Phosphorylation
S190 Phosphorylation
K200 Acetylation
S204 Phosphorylation
K214 Acetylation
K221 Acetylation
S227 Phosphorylation
S229 Phosphorylation
S245 Phosphorylation
S259 Phosphorylation
S264 Phosphorylation
T265 Phosphorylation
T293 Phosphorylation
S294 Phosphorylation
S303 Phosphorylation
T308 Phosphorylation
K353 Ubiquitination
S373 Phosphorylation
S376 Phosphorylation
S378 Phosphorylation
T400 Phosphorylation
S404 Phosphorylation
S405 Phosphorylation
Y440 Phosphorylation
K456 Ubiquitination
T458 Phosphorylation
Y510 Phosphorylation
T511 Phosphorylation
C665 S-Nitrosylation
R686 Methylation
K689 Acetylation
K689 Ubiquitination

Research Backgrounds

Function:

Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

Subcellular Location:

Cytoplasm. Membrane>Peripheral membrane protein. Cell projection>Dendritic spine.
Note: CTTNBP2-binding may regulate dendritic spine distribution.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Preferentially expressed in brain.

Subunit Structure:

Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).

Family&Domains:

Belongs to the WD repeat striatin family.

Restrictive clause

 

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