PCTK2 Antibody - #DF10139

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Product: PCTK2 Antibody
Catalog: DF10139
Description: Rabbit polyclonal antibody to PCTK2
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 60 kDa; 60kD(Calculated).
Uniprot: Q00537
RRID: AB_2840719

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Zebrafish(87%), Bovine(93%), Horse(100%), Sheep(93%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
PCTK2 Antibody detects endogenous levels of total PCTK2.
RRID:
AB_2840719
Cite Format: Affinity Biosciences Cat# DF10139, RRID:AB_2840719.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

6430598J10Rik; CDK17; CDK17_HUMAN; Cell division protein kinase 17; Cyclin-dependent kinase 17; EC 2.7.1.37; MGC25109; PCTAIRE-motif protein kinase 2; PCTK2; Protein kinase cdc2-related PCTAIRE-2; Serine/threonine-protein kinase PCTAIRE-2;

Immunogens

Immunogen:
Uniprot:

Q00537(CDK17_HUMAN) >>Visit HPA database.

Gene(ID):
CDK17(5128)
Sequence:
MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Bovine
93
Sheep
93
Zebrafish
87
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q00537 As Substrate

Site PTM Type Enzyme
S9 Phosphorylation
T11 Phosphorylation
K37 Ubiquitination
S64 Phosphorylation
S75 Phosphorylation
S80 Phosphorylation
S92 Phosphorylation
S105 Phosphorylation
S122 Phosphorylation
T124 Phosphorylation
S137 Phosphorylation
K143 Ubiquitination
S146 Phosphorylation
K160 Ubiquitination
S165 Phosphorylation
S176 Phosphorylation
S180 Phosphorylation
S182 Phosphorylation
K188 Ubiquitination
K194 Ubiquitination
K197 Ubiquitination
T202 Phosphorylation
Y203 Phosphorylation
T205 Phosphorylation
Y207 Phosphorylation
K208 Ubiquitination
K212 Ubiquitination
K221 Ubiquitination
K243 Ubiquitination
K246 Ubiquitination
K275 Ubiquitination
K315 Ubiquitination
K324 Ubiquitination
K328 Methylation
K328 Ubiquitination
K338 Ubiquitination
K423 Ubiquitination
K431 Ubiquitination
S444 Phosphorylation
K452 Ubiquitination
K459 Ubiquitination
K469 Acetylation
K469 Ubiquitination
S491 Phosphorylation
K493 Ubiquitination
K499 Ubiquitination
K515 Ubiquitination
S520 Phosphorylation

PTMs - Q00537 As Enzyme

Substrate Site Source
Q00537-1 (CDK17) S9 Uniprot
Q00537-1 (CDK17) S137 Uniprot
Q00537-1 (CDK17) S146 Uniprot
Q00537-1 (CDK17) S180 Uniprot

Research Backgrounds

Function:

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).

Subunit Structure:

Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7 (By similarity).

Family&Domains:

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

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