TSSK1 Antibody - #DF10144
| Product: | TSSK1 Antibody |
| Catalog: | DF10144 |
| Description: | Rabbit polyclonal antibody to TSSK1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog |
| Mol.Wt.: | 42 kDa; 42kD(Calculated). |
| Uniprot: | Q9BXA7 |
| RRID: | AB_2840724 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF10144, RRID:AB_2840724.
Fold/Unfold
FKSG81; serine/threonine kinase 22D (spermiogenesis associated); serine/threonine kinase FKSG81; Serine/threonine-protein kinase 22A; spermiogenesis associated 4; SPOGA1; SPOGA4; STK22A; STK22D; Testis specific kinase 1; Testis specific serine kinase 1; testis specific serine kinase 1B; Testis-specific kinase 1; Testis-specific serine/threonine-protein kinase 1; TSK 1; TSK-1; TSK1; TSSK-1; TSSK1_HUMAN; Tssk1b;
Immunogens
- Q9BXA7 TSSK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BXA7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K159 | Acetylation | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| T174 | Phosphorylation | Q9BXA7 (TSSK1B) | Uniprot |
| Y197 | Phosphorylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| Y216 | Phosphorylation | Uniprot | |
| S279 | Phosphorylation | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot |
Research Backgrounds
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.
Autophosphorylated.
Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.
Cytoplasm. Cytoplasmic vesicle>Secretory vesicle>Acrosome. Cell projection>Cilium>Flagellum.
Note: In spermatozoa, present in the sperm head and in the flagellum.
Testis-specific. Present in sperm (at protein level).
Interacts with TSSK2. Interacts with HSP90; this interaction stabilizes TSSK1 (By similarity).
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
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