NRBP1 Antibody - #DF10146
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| Product: | NRBP1 Antibody |
| Catalog: | DF10146 |
| Description: | Rabbit polyclonal antibody to NRBP1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 60 kDa; 60kD(Calculated). |
| Uniprot: | Q9UHY1 |
| RRID: | AB_2840726 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF10146, RRID:AB_2840726.
Fold/Unfold
BCON3; MADM; MUDPNP; Multiple domain putative nuclear protein; Myeloid leukemia factor 1 adaptor molecule; NRBP; NRBP_HUMAN; NRBP1; Nuclear receptor binding protein; Nuclear receptor-binding protein;
Immunogens
- Q9UHY1 NRBP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UHY1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| T8 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| K134 | Acetylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| Y152 | Phosphorylation | Uniprot | |
| T225 | Phosphorylation | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| T232 | Phosphorylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| S422 | Phosphorylation | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| T431 | Phosphorylation | Uniprot | |
| T433 | Phosphorylation | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K517 | Ubiquitination | Uniprot | |
| S535 | Phosphorylation | Uniprot |
Research Backgrounds
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.
Cytoplasm>Cell cortex. Endomembrane system. Cell projection>Lamellipodium.
Note: Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.
Ubiquitously expressed in all tissues examined with high levels in the testis.
Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity).
The protein kinase domain is predicted to be catalytically inactive.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
References
Application: WB Species: Human Sample: HK-2 cells
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