PTBP2 Antibody - #DF2956
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2956, RRID:AB_2840940.
Fold/Unfold
brPTB; FLJ34897; MIBP; Neural polypyrimidine tract binding protein; Neural polypyrimidine tract-binding protein; Neurally enriched homolog of PTB; Neurally-enriched homolog of PTB; nPTB 5; nPTB 6; nPTB 7; nPTB 8; nPTB; nPTB5; nPTB6; nPTB7; nPTB8; Polypyrimidine tract binding protein 2; Polypyrimidine tract-binding protein 2; PTB; PTB like; PTB like protein; PTB-like protein; PTBLP; PTBP 2; Ptbp2; PTBP2_HUMAN; Splicing regulator;
Immunogens
Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues.
- Q9UKA9 PTBP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDGIVTEVAVGVKRGSDELLSGSVLSSPNSNMSSMVVTANGNDSKKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKTDNTLNQRAQAVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLLAVPGALSPLAIPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVSFSKSTI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UKA9 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| K84 | Sumoylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| Y127 | Phosphorylation | Uniprot | |
| K137 | Sumoylation | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| K215 | Sumoylation | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| S269 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| K483 | Ubiquitination | Uniprot | |
| K528 | Acetylation | Uniprot | |
| K528 | Ubiquitination | Uniprot | |
| S529 | Phosphorylation | Uniprot | |
| T530 | Phosphorylation | Uniprot |
Research Backgrounds
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.
Nucleus.
Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues.
Monomer. Interacts with NOVA1; the interaction is direct. Interacts with NOVA2; the interaction is direct (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Part of a ternary complex containing KHSRP and HNRPH1.
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