prouty 4 Antibody - #DF7509
| Product: | prouty 4 Antibody |
| Catalog: | DF7509 |
| Description: | Rabbit polyclonal antibody to prouty 4 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 33 kDa.; 33kD(Calculated). |
| Uniprot: | Q9C004 |
| RRID: | AB_2841008 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF7509, RRID:AB_2841008.
Fold/Unfold
Protein sprouty homolog 4; Sprouty homolog 4; sprouty homolog 4 (Drosophila); SPRY 4; Spry-4; Spry4; SPY4_HUMAN;
Immunogens
- Q9C004 SPY4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPPIPQSAPLTPNSVMVQPLLDSRMSHSRLQHPLTILPIDQVKTSHVENDYIDNPSLALTTGPKRTRGGAPELAPTPARCDQDVTHHWISFSGRPSSVSSSSSTSSDQRLLDHMAPPPVADQASPRAVRIQPKVVHCQPLDLKGPAVPPELDKHFLLCEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSCSRSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKHTNSVICKAASGDAKTSRPDKPF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9C004 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T12 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| Y52 | Phosphorylation | Uniprot | |
| T77 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| K276 | Ubiquitination | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| K284 | Ubiquitination | Uniprot |
Research Backgrounds
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.
Cytoplasm. Cell projection>Ruffle membrane>Peripheral membrane protein>Cytoplasmic side.
Interacts with the C-terminus of TESK1. Interacts with RAF1.
The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
Belongs to the sprouty family.
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